Comparison of the efficacy and safety of a 730 nm picosecond titanium sapphire laser and a 755 nm picosecond alexandrite laser for the treatment of freckles in Asian patients: A two‐center randomized, split‐face, controlled trial

• Published in: Lasers in surgery and medicine 2023-09, Vol.55 (7), p.636-641
• Main Authors: Zhang, Mengli, Zheng, Huiying, Ge, Yiping, Yang, Yin, Guo, Lifang, Wu, Qiuju, Zeng, Rong, Shi, Hualing, Huang, Yuqing, Zhao, Wenwen, Cai, Pingping, Zhao, Hongyi, Lin, Tong
• Format: Article
• Language: English
• Subjects: alexandrite laser; Aluminum Oxide; freckles; Humans; Lasers, Solid-State - therapeutic use; Melanosis; Pain; picosecond laser; pigmentary disorder; Titanium; titanium sapphire laser; Treatment Outcome
• ISSN: 0196-8092; 1096-9101
• DOI: 10.1002/lsm.23679

Objective The 730 nm picosecond titanium sapphire laser is a novel laser that shows promising results in treating freckles. This study aimed to further investigate the efficacy and safety of the 730 nm picosecond titanium sapphire laser for treating freckles in Asian patients compared with those of the 755 nm picosecond alexandrite laser. Methods Each face of 86 participants was split into two parts and randomly assigned either one session of 730 or 755 nm picosecond‐laser treatment each. Efficacy and safety were determined based on blinded visual evaluations and self‐reports at each follow‐up visit. Results The treatment outcomes of the 730 nm picosecond laser for the treatment of freckles were comparable to those of the 755 nm picosecond laser, with 68.99 ± 7.42% and 69.27 ± 7.75% clearance, respectively (p > 0.05). Participants achieved similar Global Aesthetic Improvement Scale scores (4.04 ± 0.31 vs. 4.02 ± 0.30, respectively [p > 0.05]). Additionally, the 730 nm picosecond laser was perceived to be less painful than the 755 nm picosecond laser (4.69 ± 1.63 vs. 5.65 ± 1.80 nm, p