Synthesis and Characterization of Novel Biodegradable Copolymers of 5-Benzyloxy-1,3-dioxan-2-one and Glycolide

A series of novel biodegradable random copolymers of 5‐benzyloxy‐1,3‐dioxan‐2‐one (5‐benzyloxy‐trimethylene carbonate, BTMC) and glycolide were synthesized by ring‐opening polymerization. The copolymers were characterized by nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatogr...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2003-12, Vol.24 (18), p.1066-1069
Main Authors: Cheng, Si-Xue, Miao, Zhi-Mei, Wang, Lian-Sheng, Zhuo, Ren-Xi
Format: Article
Language:English
Subjects:
Applied sciences
biodegradable
Copolymerization
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
polycarbonates
polyesters
Preparation, kinetics, thermodynamics, mechanism and catalysts
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Summary:A series of novel biodegradable random copolymers of 5‐benzyloxy‐1,3‐dioxan‐2‐one (5‐benzyloxy‐trimethylene carbonate, BTMC) and glycolide were synthesized by ring‐opening polymerization. The copolymers were characterized by nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC). The incorporation of BTMC units into the copolymer chains results in good solubility of the polymers in common solvents. The in vitro degradation rate can be tailored by adjusting the composition of the copolymers. The in vitro degradation of the homopolymers and poly(BTMC‐co‐GA) copolymers.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.200300085