Enhancement of Biomolecular Recognition of DTIC Based on Functional Monodisperse Polystyrene Spheres

Monodisperse carboxy polystyrene (PS) spheres were synthesized and utilized as an interface to increase the detection sensitivity of some biomolecules. The binding behavior of dacarbazine (DTIC), an anticancer drug, with DNA bases in the absence and presence of the PS spheres was investigated. The r...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2005-09, Vol.26 (18), p.1469-1472
Main Authors: Zhang, Renyun, Chen, Haihua, Wu, Chunhui, Wang, Xuemei, Gu, Zhongze
Format: Article
Language:English
Subjects:
absorption spectroscopy
Applied sciences
biomolecular recognition
carboxy functional monodisperse polystyrene sphere
electrochemistry
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Properties and characterization
spherulites
Surface properties
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Summary:Monodisperse carboxy polystyrene (PS) spheres were synthesized and utilized as an interface to increase the detection sensitivity of some biomolecules. The binding behavior of dacarbazine (DTIC), an anticancer drug, with DNA bases in the absence and presence of the PS spheres was investigated. The results indicated a remarkable effect of PS on the binding behavior of DTIC to DNA bases and significantly enhanced detection sensitivity for the relative biomolecular recognition. Electrochemical detection of DTIC on a GCE surface in the absence and presence of polystyrene spheres.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.200500401