Biophysical characterization of the complexation of C 60 fullerene with doxorubicin in a prokaryotic model: Biophysikalische Charakterisierung der Komplexierung von C 60 ‐Fulleren mit Doxorubicin in einem prokaryotischen Modell

By means of small‐angle neutron scattering and ames mutagenicity test it was shown that C 60 fullerene may act as an interceptor of the antibiotic doxorubicin by formation of a hetero‐complex with this drug. This result has been predicted based on previously developed model of chemico‐biological int...

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Bibliographic Details
Published in:Materialwissenschaft und Werkstofftechnik 2016-03, Vol.47 (2-3), p.92-97
Main Authors: Prylutskyy, Y., Borowik, A., Gołuński, G., Woziwodzka, A., Piosik, J., Kyzyma, O., Pashkova, I., Ritter, U., Evstigneev, M.
Format: Article
Language:English
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Summary:By means of small‐angle neutron scattering and ames mutagenicity test it was shown that C 60 fullerene may act as an interceptor of the antibiotic doxorubicin by formation of a hetero‐complex with this drug. This result has been predicted based on previously developed model of chemico‐biological interaction between DNA‐binding drugs and aromatic interceptor molecules.
ISSN:0933-5137
1521-4052
DOI:10.1002/mawe.201600463