Electronically rotated and translated field‐free line generation for open bore magnetic particle imaging

• Published in: Medical physics (Lancaster) 2017-12, Vol.44 (12), p.6225-6238
• Main Authors: Top, Can Barış, Ilbey, Serhat, Güven, Hüseyin Emre
• Format: Article
• Language: English
• Subjects: field‐free line (FFL); image reconstruction; magnetic particle imaging; magnetism; medical imaging; nanoparticles; super paramagnetic iron oxide nanoparticles; system matrix
• ISSN: 0094-2405; 2473-4209
• DOI: 10.1002/mp.12604

Purpose We propose a coil arrangement for open bore field‐free line (FFL) magnetic particle imaging (MPI) system, which is suitable for accessing the subject from the sides. The purpose of this study is twofold, to show that the FFL can be rotated and translated electronically in a volume of interest with this arrangement and to analyze the current, voltage and power requirements for a 1 T/m gradient human sized scanner for a 200 mm diameter × 200 mm height cylindrical field of view (FOV). Methods We used split coils side by side with alternating current directions to generate a field‐free line. Employing two of these coil groups, one of which is rotated 90 degrees with respect to the other, a rotating FFL was generated. We conducted numerical simulations to show the feasibility of this arrangement for three‐dimensional (3D) electronical scan of the FFL. Using simulations, we obtained images of a two‐dimensional (2D) in silico dot phantom for a human size scanner with system matrix‐based reconstruction. Results Simulations showed that the FFL can be generated and rotated in one plane and can be translated in two axes, allowing for 3D imaging of a large subject with the proposed arrangement. Human sized scanner required 63–215 kW power for the selection field coils to scan the focus inside the FOV. Conclusions The proposed setup is suitable for FFL MPI imaging with an open bore configuration without the need for mechanical rotation, which is preferable for clinical usage in terms of imaging time and patient access. Further studies are necessary to determine the limitations imposed by peripheral nerve stimulation, and to optimize the system parameters and the sequence design.