Toward vendor-independent measurement of cerebral venous oxygenation: Comparison of TRUST MRI across three major MRI manufacturers and association with end-tidal CO 2

• Published in: NMR in biomedicine 2023-10, Vol.36 (10), p.e4990
• Main Authors: Eldirdiri, Abubakr, Zhuo, Jiachen, Lin, Zixuan, Lu, Hanzhang, Gullapalli, Rao P, Jiang, Dengrong
• Format: Article
• Language: English
• Subjects: Brain - diagnostic imaging; Brain Diseases; Carbon Dioxide; Healthy Volunteers; Humans; Magnetic Resonance Imaging - methods; Reproducibility of Results
• ISSN: 0952-3480; 1099-1492
• DOI: 10.1002/nbm.4990

Cerebral venous oxygenation (Y ) is a valuable biomarker for a variety of brain diseases. T relaxation under spin tagging (TRUST) MRI is a widely used method for Y quantification. In this work, there were two main objectives. The first was to evaluate the reproducibility of TRUST Y measurements across MRI scanners from different vendors. The second was to examine the correlation between Y and end-tidal CO (EtCO ) in a multisite, multivendor setting and determine the usefulness of this correlation to account for variations in Y caused by normal variations and physiological fluctuations. Standardized TRUST pulse sequences were implemented on three scanners from major MRI vendors (GE, Siemens, Philips). These scanners were located at two research institutions. Ten healthy subjects were scanned. On each scanner, the subject underwent two scan sessions, each of which included three TRUST scans, to evaluate the intrasession and intersession reproducibility of Y . Each scanner was also equipped with a capnograph device to record the EtCO of the subject during the MRI scan. We found no significant bias in Y measurements across the three scanners (P = 0.18). The measured Y values on the three scanners were also strongly correlated with each other (intraclass correlation coefficients > 0.85, P