Metabolic profile of the hippocampus of Zucker Diabetic Fatty rats assessed by in vivo 1 H magnetic resonance spectroscopy

Localized in vivo 1 H magnetic resonance spectroscopy (MRS) was used to investigate metabolite levels in the brain of adult Zucker Diabetic Fatty (ZDF) rats, an animal model for type 2 diabetes mellitus. This study focussed on the hippocampus, assumed to be one of the main brain areas affected by th...

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Published in:NMR in biomedicine 2004-10, Vol.17 (6), p.405-410
Main Authors: van der Graaf, Marinette, Janssen, Susan W. J., van Asten, Jack J. A., Hermus, Ad R. M. M., (Fred) Sweep, C. G. J., Pikkemaat, Jeroen A., Martens, Gerard J. M., Heerschap, Arend
Format: Article
Language:English
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Summary:Localized in vivo 1 H magnetic resonance spectroscopy (MRS) was used to investigate metabolite levels in the brain of adult Zucker Diabetic Fatty (ZDF) rats, an animal model for type 2 diabetes mellitus. This study focussed on the hippocampus, assumed to be one of the main brain areas affected by this disease. Together with an almost 5‐fold increase in blood glucose concentration measured by glucose oxidation, significant increases were found in the hippocampal concentrations of glucose (4.93 vs 1.66 m M p  
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.896