Stimulation of trigeminal motoneurons by in vivo implantation of glutamate-impregnated microspheres

The objective of this study was to alter biomechanical forces generated by the muscles of mastication that affect the growth of the craniofacial skeleton through the implantation of neurotransmitter microspheres to stimulate trigeminal motoneurons (TMNe) in vivo. Polyanhydride microspheres containin...

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Bibliographic Details
Published in:Polymers for advanced technologies 1992-10, Vol.3 (6), p.337-344
Main Authors: Byrd, Kenneth E., Domb, Abraham J., Sokoloff, Alan J., Hamilton-Byrd, Elizabeth L.
Format: Article
Language:English
Subjects:
Glutamate
Microsphere
Motoneuron
Polyanhydride
Trigeminal
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Summary:The objective of this study was to alter biomechanical forces generated by the muscles of mastication that affect the growth of the craniofacial skeleton through the implantation of neurotransmitter microspheres to stimulate trigeminal motoneurons (TMNe) in vivo. Polyanhydride microspheres containing L‐glutamate were stereotaxically implanted 170–920 μm rostral to the left‐side trigeminal motor nucleus (TMNu) in 17 Sprague–Dawley rats at 33–38 days old. Seven rats received blank‐microsphere implants and two rats had empty delivery system penetration as controls. All rats were killed 10–14 days postsurgical for dissection, brain histology, osteometric data, and SEM analyses. Dimensions of the facial skeletons of glutamate‐microsphere rats showed significant (P
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.1992.220030609