Influence of poly(N-isopropylacrylamide) and poly(N,N′-diethyl acrylamide) coatings on polysulfone/polyacrylonitrile-based membranes for protein separation

Herein we describe the design and the assembly of temperature sensitive polysulfone (PS)/polyacrylonitrile (PAN) blend membranes using supercritical fluid technology. Blended membranes were prepared using the CO2‐assisted phase inversion method, and their pores were coated with two thermoresponsive...

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Bibliographic Details
Published in:Polymers for advanced technologies 2012-10, Vol.23 (10), p.1381-1393
Main Authors: Barroso, Telma, Viveiros, Raquel, Coelho, Margarida, Casimiro, Teresa, Botelho do Rego, Ana M., Aguiar-Ricardo, Ana
Format: Article
Language:English
Subjects:
hydrogels
protein filtration
supercritical carbon dioxide
thermoresponsive membranes
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Summary:Herein we describe the design and the assembly of temperature sensitive polysulfone (PS)/polyacrylonitrile (PAN) blend membranes using supercritical fluid technology. Blended membranes were prepared using the CO2‐assisted phase inversion method, and their pores were coated with two thermoresponsive hydrogels‐poly(N‐isopropylacrylamide) (PNIPAAm) and poly(N,N′‐diethylacrylamide) (PDEAAm). Permeation experiments of bovine serum albumin (BSA) and lysozyme (LYS) solutions were used to evaluate the performance and temperature‐responsive behavior of coated membranes. While membranes coated with PNIPAAm presented similar protein permeation profiles at temperatures below and above its lower critical solution temperature, PDEAAm coating imparted a temperature‐responsive behavior to PS/PAN (90:10) membranes and selective permeation of proteins with different sizes. Copyright © 2011 John Wiley & Sons, Ltd.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.2057