Pulmonary function studies in children treated by chemoradiotherapy and stem cell transplantation

Background Management of pediatric patients with malignant and hematological diseases is frequently associated with pulmonary complications. We assessed pulmonary function at diagnosis and during a 5‐year follow‐up to identify risk factors associated with pulmonary deterioration. Procedure Ninety pa...

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Bibliographic Details
Published in:Pediatric blood & cancer 2008-11, Vol.51 (5), p.684-688
Main Authors: Efrati, Ori, Toren, Amos, Duskin, Hadar, Modan-Moses, Dalit, Bielorai, Bella, Goldstein, Gal, Churi, Chaim, Vilozni, Daphna
Format: Article
Language:English
Subjects:
acute lymphoblastic leukemia
Adolescent
Adult
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Bronchiolitis Obliterans - etiology
Child
Child, Preschool
Combined Modality Therapy
Female
Graft vs Host Disease - etiology
Hodgkin lymphoma
Humans
Lung - drug effects
Lung - radiation effects
lung function tests
Male
Neoplasms - therapy
Radiotherapy - adverse effects
Respiratory Function Tests
stem cell transplantation
Stem Cell Transplantation - adverse effects
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Summary:Background Management of pediatric patients with malignant and hematological diseases is frequently associated with pulmonary complications. We assessed pulmonary function at diagnosis and during a 5‐year follow‐up to identify risk factors associated with pulmonary deterioration. Procedure Ninety patients (age range 3–20) who were treated at the Pediatric Hematology‐Oncology Department, Sheba Medical Center, Israel, were entered into the study. Pulmonary function testing was performed at diagnosis and at least twice during the study period. Results At diagnosis and thereafter values of spirometry, total lung capacity, functional residual capacity and diffusion capacity were significantly lower than predicted (P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.21722