Predictive factors of internalized and externalized behavioral problems in children treated for acute lymphoblastic leukemia

Background Pediatric cancer survivors are at increased risk of various neurological and psychological problems. The prevalence of behavioral problems was assessed in a longitudinal study in pediatric patients with an acute lymphoblastic leukemia (ALL). Multilevel modeling was used to identify associ...

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Bibliographic Details
Published in:Pediatric blood & cancer 2012-06, Vol.58 (6), p.971-977
Main Authors: Marcoux, Sophie, Robaey, Philippe, Krajinovic, Maja, Moghrabi, Albert, Laverdière, Caroline
Format: Article
Language:English
Subjects:
acute lymphoblastic leukemia
Antineoplastic Combined Chemotherapy Protocols - adverse effects
behavioral problems
Child
Child Behavior Disorders - epidemiology
Child Behavior Disorders - etiology
corticosteroids
Female
Humans
Longitudinal Studies
Male
Mothers - psychology
Neuropsychological Tests
pediatric cancer
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - psychology
Prevalence
Risk Factors
Stress, Psychological - complications
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Summary:Background Pediatric cancer survivors are at increased risk of various neurological and psychological problems. The prevalence of behavioral problems was assessed in a longitudinal study in pediatric patients with an acute lymphoblastic leukemia (ALL). Multilevel modeling was used to identify associated predictive factors. Procedure ALL patients and their parents (n = 138) took part to this study. Patients were treated according to the Dana‐Farber Cancer Institute (DFCI) consortium protocols 91‐01 or 95‐01. Mothers filled out questionnaires providing a measure of behavioral problems for their child at diagnosis and during the subsequent 4 years, and of their perceived familial stress at diagnosis and post‐induction. Results Prevalence of internalized behavioral problems at diagnosis was increased [42% above 1 standard deviation (SD); P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.24079