Evidence of hydroxyurea activity in children with pretreated desmoid‐type fibromatosis: A new option in the armamentarium of systemic therapies

Introduction The treatment paradigm in desmoid‐type fibromatosis (DF) has changed in recent years from a surgery‐based strategy to a multidisciplinary approach that includes systemic therapies. Among various medical therapies, hydroxyurea has been considered of potential interest. This case series s...

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Bibliographic Details
Published in:Pediatric blood & cancer 2019-01, Vol.66 (1), p.e27472-n/a
Main Authors: Ferrari, Andrea, Orbach, Daniel, Affinita, Maria Carmen, Chiaravalli, Stefano, Corradini, Nadege, Meazza, Cristina, Bisogno, Gianni, Casanova, Michela
Format: Article
Language:English
Subjects:
aggressive fibromatosis
chemotherapy
children
desmoid‐type fibromatosis
hydroxyurea
new drug
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Summary:Introduction The treatment paradigm in desmoid‐type fibromatosis (DF) has changed in recent years from a surgery‐based strategy to a multidisciplinary approach that includes systemic therapies. Among various medical therapies, hydroxyurea has been considered of potential interest. This case series summarizes the experience gained at four centers using hydroxyurea in relapsing DF. Methods Eligibility requirements were age 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.27472