The relationship between ventricular volume and whole‐brain irradiation dose in central nervous system germ cell tumors

Background Advanced irradiation techniques, including intensity‐modulated radiation therapy (IMRT), aim to limit irradiation to adjoining tissues by conforming beams to a well‐defined volume. In intracranial germinomas, whole‐ventricular IMRT decreases the volume of irradiation to surrounding parenc...

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Bibliographic Details
Published in:Pediatric blood & cancer 2019-12, Vol.66 (12), p.e28005-n/a
Main Authors: Toll, Stephanie A., Jones, Marjorie T., Yoshida, Emi J., Dhall, Girish, Olch, Arthur J., Wong, Kenneth K.
Format: Article
Language:English
Subjects:
Adolescent
Adult
brain tumors
Central Nervous System Neoplasms - pathology
Central Nervous System Neoplasms - radiotherapy
Cerebral Ventricles - pathology
Cerebral Ventricles - radiation effects
Child
Child, Preschool
CNS germ cell tumors
Cranial Irradiation - methods
Female
Follow-Up Studies
Humans
Male
Neoplasms, Germ Cell and Embryonal - pathology
Neoplasms, Germ Cell and Embryonal - radiotherapy
Organs at Risk - radiation effects
Prognosis
radiation oncology
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Intensity-Modulated - methods
Retrospective Studies
ventricular volume
Young Adult
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Summary:Background Advanced irradiation techniques, including intensity‐modulated radiation therapy (IMRT), aim to limit irradiation to adjoining tissues by conforming beams to a well‐defined volume. In intracranial germinomas, whole‐ventricular IMRT decreases the volume of irradiation to surrounding parenchyma. This study examined the relationship between ventricular volume and radiation dose to surrounding tissue. Procedure We retrospectively reviewed age, sex, ventricular and brain volume, ventricular dose, and volume of brain that received 12 Gy (V12) for patients diagnosed with germ cell tumors at our institution treated with whole‐ventricular IMRT between 2002 and 2016. Variables were assessed for correlation and statistical significance. Results Forty‐seven patients were analyzed. The median whole‐ventricular irradiation dose was 24 Gy with a median boost dose of 30 Gy. The median ventricular volume was 234.3 cm3, and median brain volume was 1408 cm3. There was no significant difference between mean ventricular volume of suprasellar versus pineal tumors (P = .95). The median V12 of the brain, including the ventricles, was 58.9%. The strongest correlation was between ventricular volume and V12, with an r2 (coefficient of determination) of .47 (P 
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.28005