βLG values in mechanistic studies on the transesterification of RNA models and their application in a metal ion complex promoted transesterification

Studies on the mechanism of transesterification reactions of nucleoside 3′‐phosphoesters using βLG values as a mechanistic tool are discussed in this mini review. Our recent observation that a dinuclear metal ion complex enhances both the cleavage and isomerisation is discussed in the light of previ...

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Bibliographic Details
Published in:Journal of physical organic chemistry 2013-02, Vol.26 (2), p.182-186
Main Authors: Korhonen, Heidi, Williams, Nicholas H., Mikkola, Satu
Format: Article
Language:English
Subjects:
catalysis
mechanism
metal ion complexes
RNA
transesterification
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Summary:Studies on the mechanism of transesterification reactions of nucleoside 3′‐phosphoesters using βLG values as a mechanistic tool are discussed in this mini review. Our recent observation that a dinuclear metal ion complex enhances both the cleavage and isomerisation is discussed in the light of previous studies. Copyright © 2012 John Wiley & Sons, Ltd. βLG values reported for the transesterification of phosphodiester bonds ribonucleoside 3′‐alkyl and 3′‐dialkyl phosphates under various conditions, as well as the mechanistic interpretation of the values, is discussed in this review.
ISSN:0894-3230
1099-1395
DOI:10.1002/poc.2942