GST-P1 as a histological biomarker of synovial sarcoma revealed by proteomics

Synovial sarcoma have two histological subtypes, biphasic and monophasic, defined respectively by the presence or absence of glandular epithelial differentiation. To develop histological biomarkers for synovial sarcoma subtypes, we examined the proteomic profile using two‐dimensional difference gel...

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Bibliographic Details
Published in:Proteomics. Clinical applications 2009-05, Vol.3 (5), p.623-634
Main Authors: Suehara, Yoshiyuki, Kikuta, Kazutaka, Nakayama, Robert, Tochigi, Naobumi, Seki, Kunihiko, Ichikawa, Hitoshi, Fujii, Kiyonaga, Hasegawa, Tadashi, Shimoda, Tadakazu, Kurosawa, Hisashi, Chuman, Hirokazu, Beppu, Yasuo, Kawai, Akira, Hirohashi, Setsuo, Kondo, Tadashi
Format: Article
Language:English
Subjects:
2-D DIGE
Biological and medical sciences
Diseases of the osteoarticular system
Diverse techniques
Fundamental and applied biological sciences. Psychology
GST-P1
Medical sciences
Molecular and cellular biology
Proteomics
Synovial sarcoma
Tumors of striated muscle and skeleton
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Summary:Synovial sarcoma have two histological subtypes, biphasic and monophasic, defined respectively by the presence or absence of glandular epithelial differentiation. To develop histological biomarkers for synovial sarcoma subtypes, we examined the proteomic profile using two‐dimensional difference gel electrophoresis. We identified 29 protein spots whose intensity was statistically different between the monophasic (15 cases) and biphasic (9 cases) subtypes (p
ISSN:1862-8346
1862-8354
DOI:10.1002/prca.200800211