Front Cover: Cardiomyocyte Proteome Remodeling due to Isoproterenol‐Induced Cardiac Hypertrophy during the Compensated Phase

Abnormal activation of the sympathetic nervous system can induce cardiac hypertrophy and ultimately heart failure. To shed lights into the downstream effectors of the earlier stages of pathological hypertrophy, mice were treated for seven days with isoproterenol and cardiomyocytes isolated from hype...

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Bibliographic Details
Published in:Proteomics. Clinical applications 2020-07, Vol.14 (4), p.n/a
Main Authors: Parreira, Ricardo Cambraia, Gómez‐Mendoza, Diana Paola, Jesus, Itamar Couto Guedes, Lemos, Rafael Pereira, Santos, Anderson Kennedy, Rezende, Cristiana Perdigão, Figueiredo, Henrique César Pereira, Pinto, Mauro Cunha Xavier, Kjeldsen, Frank, Guatimosim, Silvia, Resende, Rodrigo Ribeiro, Verano‐Braga, Thiago
Format: Article
Language:English
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Summary:Abnormal activation of the sympathetic nervous system can induce cardiac hypertrophy and ultimately heart failure. To shed lights into the downstream effectors of the earlier stages of pathological hypertrophy, mice were treated for seven days with isoproterenol and cardiomyocytes isolated from hypertrophic hearts were studied by proteomics. Potential earlier markers for heart failure and therapeutic targets are reported. This is reported by Ricardo Cambraia Parreira, Diana Paola Gómez‐Mendoza, Itamar Couto Guedes de Jesus, Rafael Pereira Lemos, Anderson Kennedy Santos, Cristiana Perdigão Rezende, Henrique César Pereira Figueiredo, Mauro Cunha Xavier Pinto, Frank Kjeldsen, Silvia Guatimosim, Rodrigo Ribeiro Resende, Thiago Verano‐Braga in article 2000017.
ISSN:1862-8346
1862-8354
DOI:10.1002/prca.202070041