Structure of the lysine specific protease K gp from P orphyromonas gingivalis , a target for improved oral health

The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell‐surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical...

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Published in:Protein science 2015-01, Vol.24 (1), p.162-166
Main Authors: Gorman, Michael A., Seers, Christine A., Michell, Belinda J., Feil, Susanne C., Huq, N. Laila, Cross, Keith J., Reynolds, Eric C., Parker, Michael W.
Format: Article
Language:English
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Summary:The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell‐surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis . We have determined the X‐ray crystal structure of the lysine‐specific protease domain of Kgp to 1.6 Å resolution. The structure provides insights into the mechanism of substrate specificity and catalysis. PDB Code(s): 4TKX
ISSN:0961-8368
1469-896X
DOI:10.1002/pro.2589