Genome-wide scan for linkage in finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26

• Published in: The Prostate 2003-12, Vol.57 (4), p.280-289
• Main Authors: Schleutker, Johanna, Baffoe-Bonnie, Agnes B., Gillanders, Elizabeth, Kainu, Tommi, Jones, Mary-Pat, Freas-Lutz, Diana, Markey, Carol, Gildea, Derek, Riedesel, Erica, Albertus, Julie, Gibbs Jr, Kenneth D., Matikainen, Mika, Koivisto, Pasi A., Tammela, Teuvo, Bailey-Wilson, Joan E., Trent, Jeffrey M., Kallioniemi, Olli-P.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; cancer predisposition; Chromosomes, Human, Pair 11 - genetics; Chromosomes, Human, Pair 3 - genetics; DNA, Neoplasm - chemistry; DNA, Neoplasm - genetics; familiar cancer; Family; Female; Finland; Genetic Linkage - genetics; Genetic Predisposition to Disease; genetic susceptibility; Genome, Human; homogeneous population; Humans; Male; Medical sciences; Microsatellite Repeats - genetics; Middle Aged; Nephrology. Urinary tract diseases; Polymerase Chain Reaction; Prostatic Neoplasms - genetics; Sequence Analysis, DNA; Statistics, Nonparametric; Stomach Neoplasms - genetics; Tumors of the urinary system; Urinary tract. Prostate gland
• ISSN: 0270-4137; 1097-0045
• DOI: 10.1002/pros.10302

BACKGROUND In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome‐wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families. METHODS Altogether 87 DNA samples were genotyped from 13 families. Logarithm‐of‐odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown. RESULTS The highest LOD scores in the affected‐only analyses were found at 11q14, where the two‐point LOD score was 2.97 (θ = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non‐parametric‐linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25‐26, with a two‐point LOD score of 2.57 (θ = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02). CONCLUSIONS The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study. Prostate 57: 280–289, 2003. © 2003 Wiley‐Liss, Inc.