Antiprotozoal activity of the constituents of Teloxys graveolens

Antiprotozoal activity‐guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2003-08, Vol.17 (7), p.731-732
Main Authors: Calzada, Fernando, Velázquez, Claudia, Cedillo-Rivera, Roberto, Esquivel, Baldomero
Format: Article
Language:English
Subjects:
Amaranthaceae
Animals
antiprotozoal activity
Antiprotozoal Agents - administration & dosage
Antiprotozoal Agents - pharmacology
Antiprotozoal Agents - therapeutic use
Biological and medical sciences
Entamoeba histolytica
Entamoeba histolytica - drug effects
Entamoebiasis - drug therapy
General pharmacology
Giardia lamblia
Giardia lamblia - drug effects
Giardiasis - drug therapy
Inhibitory Concentration 50
Medical sciences
melilotoside
Parasitic Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Components, Aerial
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Teloxys graveolens
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antiprotozoal activity‐guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most potent activity toward Entamoeba histolytica and Giardia lamblia (IC50 12.5 and 16.8 µg/mL, respectively). Narcissin showed selectivity against E. histolytlica (IC50 17.2 µg/mL). The results support data for the traditional use of T. graveolens in some gastrointestinal diseases. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1192