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Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities
Herb extracts commercially used in Asia were screened for their estrogenic activity with a recombinant yeast system with both a human estrogen receptor (ER) expression plasmid and a reporter plasmid. Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 17‐estradiol = 1.00) (7.8e...
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| Published in: | Phytotherapy research 2006-11, Vol.20 (11), p.1017-1019 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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| cited_by | cdi_FETCH-LOGICAL-c4537-7187a23a07d35ebc68dfa84afe04b05cc065816e29a5ef65f8537368548f4e8a3 |
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| cites | cdi_FETCH-LOGICAL-c4537-7187a23a07d35ebc68dfa84afe04b05cc065816e29a5ef65f8537368548f4e8a3 |
| container_end_page | 1019 |
| container_issue | 11 |
| container_start_page | 1017 |
| container_title | Phytotherapy research |
| container_volume | 20 |
| creator | Kang, Se Chan Lee, Chang Min Choi, Han Lee, Jae Hyun Oh, Joa Sub Kwak, Jong Hwan Zee, Ok Pyo |
| description | Herb extracts commercially used in Asia were screened for their estrogenic activity with a recombinant yeast system with both a human estrogen receptor (ER) expression plasmid and a reporter plasmid. Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 17‐estradiol = 1.00) (7.8e‐3) (RP for + control), followed by Amomum xanthioides (1.3e‐3), Glycyrrhiza uralensis, Zingiber officinale, Rheum palmatum, Curcuma aromatica, Eriobotrya japonica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum and Pueraria lobata (root) (9.5e‐4–1.0e‐4), and Prunus persica, Lycoppus lucidus and Adenophora stricta (9.0e‐5–8.0e‐5). In the antiproliferative assay, five human cancer cell lines representing different tissues (breast, lung and ovary) were used. Eriobotrya japonica showed strong cytotoxicity in ER‐negative breast cancer (MDA‐MB‐231), cervix epitheloid (HeLa) and lung (A549) carcinoma cell lines. Copyright © 2006 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1987 |
| format | article |
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Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 17‐estradiol = 1.00) (7.8e‐3) (RP for + control), followed by Amomum xanthioides (1.3e‐3), Glycyrrhiza uralensis, Zingiber officinale, Rheum palmatum, Curcuma aromatica, Eriobotrya japonica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum and Pueraria lobata (root) (9.5e‐4–1.0e‐4), and Prunus persica, Lycoppus lucidus and Adenophora stricta (9.0e‐5–8.0e‐5). In the antiproliferative assay, five human cancer cell lines representing different tissues (breast, lung and ovary) were used. Eriobotrya japonica showed strong cytotoxicity in ER‐negative breast cancer (MDA‐MB‐231), cervix epitheloid (HeLa) and lung (A549) carcinoma cell lines. Copyright © 2006 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1987</identifier><identifier>PMID: 16906642</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>antiproliferative effects ; Asia ; beta-Galactosidase - analysis ; beta-Galactosidase - metabolism ; Biological and medical sciences ; Cell Line, Tumor ; Cell Proliferation - drug effects ; estrogen ; estrogen receptor ; Estrogens - toxicity ; General pharmacology ; Genes, Reporter ; HeLa Cells ; Humans ; Medical sciences ; Methanol - chemistry ; Organisms, Genetically Modified - physiology ; Oriental medicinal herbs ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - toxicity ; Plants, Medicinal - chemistry ; Plants, Medicinal - toxicity ; Receptors, Estrogen - drug effects ; recombinant yeast system ; Saccharomyces cerevisiae ; Toxicity Tests - methods</subject><ispartof>Phytotherapy research, 2006-11, Vol.20 (11), p.1017-1019</ispartof><rights>Copyright © 2006 John Wiley & Sons, Ltd.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2006 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4537-7187a23a07d35ebc68dfa84afe04b05cc065816e29a5ef65f8537368548f4e8a3</citedby><cites>FETCH-LOGICAL-c4537-7187a23a07d35ebc68dfa84afe04b05cc065816e29a5ef65f8537368548f4e8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18251651$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16906642$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Se Chan</creatorcontrib><creatorcontrib>Lee, Chang Min</creatorcontrib><creatorcontrib>Choi, Han</creatorcontrib><creatorcontrib>Lee, Jae Hyun</creatorcontrib><creatorcontrib>Oh, Joa Sub</creatorcontrib><creatorcontrib>Kwak, Jong Hwan</creatorcontrib><creatorcontrib>Zee, Ok Pyo</creatorcontrib><title>Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>Herb extracts commercially used in Asia were screened for their estrogenic activity with a recombinant yeast system with both a human estrogen receptor (ER) expression plasmid and a reporter plasmid. Pueraria lobata (flower) had the highest estrogenic relative potency (RP, 17‐estradiol = 1.00) (7.8e‐3) (RP for + control), followed by Amomum xanthioides (1.3e‐3), Glycyrrhiza uralensis, Zingiber officinale, Rheum palmatum, Curcuma aromatica, Eriobotrya japonica, Sophora flavescens, Anemarrhena asphodeloides, Polygonum multiflorum and Pueraria lobata (root) (9.5e‐4–1.0e‐4), and Prunus persica, Lycoppus lucidus and Adenophora stricta (9.0e‐5–8.0e‐5). In the antiproliferative assay, five human cancer cell lines representing different tissues (breast, lung and ovary) were used. Eriobotrya japonica showed strong cytotoxicity in ER‐negative breast cancer (MDA‐MB‐231), cervix epitheloid (HeLa) and lung (A549) carcinoma cell lines. Copyright © 2006 John Wiley & Sons, Ltd.</description><subject>antiproliferative effects</subject><subject>Asia</subject><subject>beta-Galactosidase - analysis</subject><subject>beta-Galactosidase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>estrogen</subject><subject>estrogen receptor</subject><subject>Estrogens - toxicity</subject><subject>General pharmacology</subject><subject>Genes, Reporter</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Methanol - chemistry</subject><subject>Organisms, Genetically Modified - physiology</subject><subject>Oriental medicinal herbs</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - toxicity</subject><subject>Plants, Medicinal - chemistry</subject><subject>Plants, Medicinal - toxicity</subject><subject>Receptors, Estrogen - drug effects</subject><subject>recombinant yeast system</subject><subject>Saccharomyces cerevisiae</subject><subject>Toxicity Tests - methods</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp10EtLxDAQB_Agirs-wE8gvQheqknbpOlRlt1V8IX4wkuYphON1rYkXR_f3sgW92QgTA6_zDB_QvYYPWKUJsdd745YIfM1Mma0KGLG83SdjGnBWZwx-TgiW96_UkqLhGabZMREQYXIkjG5n35AvYDetk3Umqh1Fpse6ugdK6ttE14v6EofmdZF6HvXPmNjdQRNFW5vO9fW1qALDT4wAh2K7S36HbJhoPa4O9Rtcjeb3k5O4_Or-dnk5DzWGU_zOGcyhyQFmlcpx1ILWRmQGRikWUm51lRwyQQmBXA0ghsZfqVC8kyaDCWk2-Rw2Ve71nuHRnXOvoP7Voyq32hUiEb9RhPo_pJ2izJst4JDFgEcDAC8hto4aLT1KycTzgRnwcVL92lr_P53oLq-vRkGD976Hr_-PLg3JfI05-rhcq4ms3CeLoSi6Q-WxorU</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Kang, Se Chan</creator><creator>Lee, Chang Min</creator><creator>Choi, Han</creator><creator>Lee, Jae Hyun</creator><creator>Oh, Joa Sub</creator><creator>Kwak, Jong Hwan</creator><creator>Zee, Ok Pyo</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200611</creationdate><title>Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities</title><author>Kang, Se Chan ; Lee, Chang Min ; Choi, Han ; Lee, Jae Hyun ; Oh, Joa Sub ; Kwak, Jong Hwan ; Zee, Ok Pyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4537-7187a23a07d35ebc68dfa84afe04b05cc065816e29a5ef65f8537368548f4e8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>antiproliferative effects</topic><topic>Asia</topic><topic>beta-Galactosidase - analysis</topic><topic>beta-Galactosidase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>estrogen</topic><topic>estrogen receptor</topic><topic>Estrogens - toxicity</topic><topic>General pharmacology</topic><topic>Genes, Reporter</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Methanol - chemistry</topic><topic>Organisms, Genetically Modified - physiology</topic><topic>Oriental medicinal herbs</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - toxicity</topic><topic>Plants, Medicinal - chemistry</topic><topic>Plants, Medicinal - toxicity</topic><topic>Receptors, Estrogen - drug effects</topic><topic>recombinant yeast system</topic><topic>Saccharomyces cerevisiae</topic><topic>Toxicity Tests - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Se Chan</creatorcontrib><creatorcontrib>Lee, Chang Min</creatorcontrib><creatorcontrib>Choi, Han</creatorcontrib><creatorcontrib>Lee, Jae Hyun</creatorcontrib><creatorcontrib>Oh, Joa Sub</creatorcontrib><creatorcontrib>Kwak, Jong Hwan</creatorcontrib><creatorcontrib>Zee, Ok Pyo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Se Chan</au><au>Lee, Chang Min</au><au>Choi, Han</au><au>Lee, Jae Hyun</au><au>Oh, Joa Sub</au><au>Kwak, Jong Hwan</au><au>Zee, Ok Pyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. 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Eriobotrya japonica showed strong cytotoxicity in ER‐negative breast cancer (MDA‐MB‐231), cervix epitheloid (HeLa) and lung (A549) carcinoma cell lines. Copyright © 2006 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16906642</pmid><doi>10.1002/ptr.1987</doi><tpages>3</tpages></addata></record> |
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| ispartof | Phytotherapy research, 2006-11, Vol.20 (11), p.1017-1019 |
| issn | 0951-418X 1099-1573 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | antiproliferative effects Asia beta-Galactosidase - analysis beta-Galactosidase - metabolism Biological and medical sciences Cell Line, Tumor Cell Proliferation - drug effects estrogen estrogen receptor Estrogens - toxicity General pharmacology Genes, Reporter HeLa Cells Humans Medical sciences Methanol - chemistry Organisms, Genetically Modified - physiology Oriental medicinal herbs Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - toxicity Plants, Medicinal - chemistry Plants, Medicinal - toxicity Receptors, Estrogen - drug effects recombinant yeast system Saccharomyces cerevisiae Toxicity Tests - methods |
| title | Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities |
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