novel cytotoxic lignan from Seseli annuum L

A new tetrahydrofuranoid lignan named seselinone was isolated from the aerial parts of Seseli annuum, together with three known lignans (eudesmin, magnone A and hernone) and prenylated coumarin umbelliprenin. Seselinone and eudesmin showed cytotoxic activity against C6 rat glioma cell cultures. Copy...

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Bibliographic Details
Published in:Phytotherapy research 2007-08, Vol.21 (8), p.790-792
Main Authors: Vučković, Ivan, Trajković, Vladimir, Macura, Slobodan, Tešević, Vele, Janaćković, Ped̄a, Milosavljević, Slobodan
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - toxicity
Apiaceae - chemistry
Biological and medical sciences
Cell Line, Tumor
cytotoxicity
eudesmin
General pharmacology
Glioma - pathology
lignans
Lignans - chemistry
Lignans - toxicity
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Components, Aerial - chemistry
Rats
Seseli annuum
seselinone
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Summary:A new tetrahydrofuranoid lignan named seselinone was isolated from the aerial parts of Seseli annuum, together with three known lignans (eudesmin, magnone A and hernone) and prenylated coumarin umbelliprenin. Seselinone and eudesmin showed cytotoxic activity against C6 rat glioma cell cultures. Copyright © 2007 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2152