Influence of silymarin and its flavonolignans on doxorubicin-iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin

Silymarin, an extract of Silybum marianum seeds, and the constituent flavonolignans silybin, silydianin and silychristin, as well as the flavonol quercetin, protected rat heart microsomes and mitochondria against iron‐dependent doxorubicin induced lipid peroxidation. Quercetin was found to be more p...

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Published in:Phytotherapy research 2002-03, Vol.16 (S1), p.63-67
Main Authors: Psotová, Jitka, Chlopčíková, Šárka, Grambal, František, Šimánek, Vilím, Ulrichová, Jitka
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Biological and medical sciences
doxorubicin
Doxorubicin - toxicity
DPPH colour reduction
Ferrous Compounds
Flavonoids - pharmacology
Flavonols
Free Radical Scavengers - pharmacology
General pharmacology
Heart - drug effects
Inhibitory Concentration 50
iron
lipid peroxidation
Lipid Peroxidation - drug effects
Medical sciences
Microsomes - drug effects
Mitochondria, Heart - drug effects
peak oxidation potentials
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - pharmacology
quercetin
Quercetin - pharmacology
rat heart microsomes
rat heart mitochondria
Rats
Rats, Wistar
Seeds
silybin
silychristin
silydianin
silymarin
Silymarin - pharmacology
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Summary:Silymarin, an extract of Silybum marianum seeds, and the constituent flavonolignans silybin, silydianin and silychristin, as well as the flavonol quercetin, protected rat heart microsomes and mitochondria against iron‐dependent doxorubicin induced lipid peroxidation. Quercetin was found to be more potent than either silymarin or its three constituents, whose cytoprotectivity was comparable. The radical scavenging activity of the compounds was investigated using a DPPH colour reduction assay and cyclic voltametry to assess their antioxidant activities. In contrast to quercetin, silybin, silydianin and silychristin did not chelate iron in aqueous solution. The results suggest that silymarin may prevent doxorubicin‐mediated damage to rat heart membrane primarily through a free radical scavenging mechanism. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.811