Screening of selected plant extracts for in vitro inhibitory activity on Human Immunodeficiency Virus

As part of our screening of anti‐AIDS agents from natural sources, extracts of 15 medicinal plants widely used in the folk medicines of North America and Europe were evaluated in vitro. Most of the extracts tested were relatively nontoxic to human lymphocytic MT‐2 cells, but only the extracts of Hys...

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Bibliographic Details
Published in:Phytotherapy research 2002-09, Vol.16 (6), p.550-554
Main Authors: Bedoya, L. M., Palomino, S. Sanchez, Abad, M. J., Bermejo, P., Alcami, J.
Format: Article
Language:English
Subjects:
AIDS
Anti-HIV Agents - pharmacology
antiviral activity
Asteraceae
Biological and medical sciences
Drug Evaluation, Preclinical - methods
Europe
Formazans
General pharmacology
HIV
HIV - drug effects
Humans
Lamiaceae
Medical sciences
medicinal plants
North America
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Extracts - toxicity
Tetrazolium Salts
Tumor Cells, Cultured
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Summary:As part of our screening of anti‐AIDS agents from natural sources, extracts of 15 medicinal plants widely used in the folk medicines of North America and Europe were evaluated in vitro. Most of the extracts tested were relatively nontoxic to human lymphocytic MT‐2 cells, but only the extracts of Hysopp officinalis and Dittrichia viscosa exhibited anti‐HIV activity in an in vitro MTT assay. The 50% hydroalcohol extract of Hysopp officinalis and the aqueous extract of Dittrichia viscosa showed inhibitory effects against HIV‐1 induced infections in MT‐2 cells at concentrations ranging from 50 to 100 μg/mL and 25 to 400 μg/mL, respectively. Both extracts showed no appreciable cytotoxicity at these concentrations. Copyright © 2002 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.992