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Long‐term clinical, nutritional, and functional outcomes of COVID‐19 patients after hospital discharge
Background Long‐term nutritional and functional status after hospitalization due to COVID‐19 has been poorly described. We show the physical and nutritional stata and the symptoms compatible with Long‐COVID in patients who survived after an episode of hospitalization due to COVID‐19 and the associat...
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| Published in: | JCSM communications 2024-07, Vol.7 (2), p.99-106 |
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| creator | Pedraza, Laura Laosa, Olga Segovia‐Moreno, Rocío Alcalá, Álvaro Tornero‐López, María Isabel Corral‐Muñoz, Germán López, Patricia Carnicero, Jose Antonio Ramirez, Maria Camprubi, Maria Rodríguez‐Mañas, Leocadio |
| description | Background
Long‐term nutritional and functional status after hospitalization due to COVID‐19 has been poorly described. We show the physical and nutritional stata and the symptoms compatible with Long‐COVID in patients who survived after an episode of hospitalization due to COVID‐19 and the associated factors.
Methods
Single‐center prospective observational study. Clinical, nutritional, and physical function data were assessed in 345 subjects over 18 years of age hospitalized in an university hospital for a diagnosis of COVID‐19 in 2020 at three different times of follow‐up: 6 (n = 118), 9 (n = 115), and 15 months (n = 112) after discharge. All survivors discharged during each of those periods were called consecutively at the times of follow‐up in order to collect data about their nutritional and functional stata, and long‐COVID symptoms.
Results
The mean age of the 345 subjects included in the present study was 62.8 years (SD 15.8), and 180 (52.2%) were men. The mean number of comorbidities was 2.6 (SD 2.1). After a mean follow‐up time of 10.2 ± 3.2 months, mean Barthel score showed a decrease of 2.00 (SD 0.12) points, that showed to be consistent disregarding the time after discharge (6 months: 1.71 ± 4.8; 9 months: 2.17 ± 5.97; 15 months: 2.20 ± 5.25). The risk factors associated with worsening in the Barthel index score were basal Barthel index [BI |
| doi_str_mv | 10.1002/rco2.97 |
| format | article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_rco2_97</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>RCO297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1017-236c8a1b03c5ab41ef9ad9e79b5e59d8e33da291f9eeba2a2e25b055f5a9a38f3</originalsourceid><addsrcrecordid>eNp1kM1KAzEcxIMoWGrxFXLzoFvz0e1ujrJ-FQoFUa_Lf7P_tCnbpCQp0puP4DP6JG6pBy-eZgZ-M4ch5JKzMWdM3AbtxVgVJ2QglJpmXKrJ6R9_TkYxrhljUgpWlOWArOfeLb8_vxKGDdWddVZDd0PdLgWbrHeHAK6lZuf0MVO_S9pvMFJvaLV4n933da7oFpJFlyIF04_RlY9bm3q8tVGvICzxgpwZ6CKOfnVI3h4fXqvnbL54mlV380xzxotMyKkugTdM6hyaCUejoFVYqCbHXLUlStmCUNwoxAYECBR5w_Lc5KBAlkYOydVxVwcfY0BTb4PdQNjXnNWHl-rDS7UqevL6SH7YDvf_YfVLtRA9_QPzdGvP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Long‐term clinical, nutritional, and functional outcomes of COVID‐19 patients after hospital discharge</title><source>Open Access: Wiley-Blackwell Open Access Journals</source><creator>Pedraza, Laura ; Laosa, Olga ; Segovia‐Moreno, Rocío ; Alcalá, Álvaro ; Tornero‐López, María Isabel ; Corral‐Muñoz, Germán ; López, Patricia ; Carnicero, Jose Antonio ; Ramirez, Maria ; Camprubi, Maria ; Rodríguez‐Mañas, Leocadio</creator><creatorcontrib>Pedraza, Laura ; Laosa, Olga ; Segovia‐Moreno, Rocío ; Alcalá, Álvaro ; Tornero‐López, María Isabel ; Corral‐Muñoz, Germán ; López, Patricia ; Carnicero, Jose Antonio ; Ramirez, Maria ; Camprubi, Maria ; Rodríguez‐Mañas, Leocadio</creatorcontrib><description>Background
Long‐term nutritional and functional status after hospitalization due to COVID‐19 has been poorly described. We show the physical and nutritional stata and the symptoms compatible with Long‐COVID in patients who survived after an episode of hospitalization due to COVID‐19 and the associated factors.
Methods
Single‐center prospective observational study. Clinical, nutritional, and physical function data were assessed in 345 subjects over 18 years of age hospitalized in an university hospital for a diagnosis of COVID‐19 in 2020 at three different times of follow‐up: 6 (n = 118), 9 (n = 115), and 15 months (n = 112) after discharge. All survivors discharged during each of those periods were called consecutively at the times of follow‐up in order to collect data about their nutritional and functional stata, and long‐COVID symptoms.
Results
The mean age of the 345 subjects included in the present study was 62.8 years (SD 15.8), and 180 (52.2%) were men. The mean number of comorbidities was 2.6 (SD 2.1). After a mean follow‐up time of 10.2 ± 3.2 months, mean Barthel score showed a decrease of 2.00 (SD 0.12) points, that showed to be consistent disregarding the time after discharge (6 months: 1.71 ± 4.8; 9 months: 2.17 ± 5.97; 15 months: 2.20 ± 5.25). The risk factors associated with worsening in the Barthel index score were basal Barthel index [BI < 95; odds ratio (OR): 3.34, 95% confidence interval (CI): 1.26–8.85], age (OR: 1.03, CI: 1.00–1.06, per year), having comorbidities (≥3 pathologies) (OR: 1.98, CI: 1.00–3.90), and female sex (OR: 2.68, CI: 1.47–4.90). Self‐reported Long‐COVID symptoms were frequent, mainly those related to functioning: fatigue/tiredness (39.4%), decreased mobility (16.2%), and subjective loss of muscle mass/strength (15.9%) plus mental complaints (depression/anxiety; 20.6%). Decreased mobility (OR 7.82, CI: 3.69–16.55), cognitive impairment (OR 6.76, CI: 2.22–20.58) and a score in SARC‐F ≥ 2 (OR: 3.89; CI: 2.03–7.49) at follow‐up were associated to the worsening in BI. BMI showed a modest, non‐significant decrease at 6 months (−0.3 ± 1.7 kg/m2), that was fully recovered in the longest follow‐up period (+0.4 ± 2.1).
Conclusions
Admission for COVID‐19 produces a significant functional loose, mainly in those who are older, female, and with a poor basal functional status and comorbidities. This impairment does not recover spontaneously and is a main component of the long‐term COVID‐19 symptoms.</description><identifier>ISSN: 2996-1394</identifier><identifier>EISSN: 2996-1394</identifier><identifier>DOI: 10.1002/rco2.97</identifier><language>eng</language><subject>COVID‐19 ; Functional status ; Long‐COVID ; Long‐term follow‐up ; Nutritional status ; Sarcopenia</subject><ispartof>JCSM communications, 2024-07, Vol.7 (2), p.99-106</ispartof><rights>2024 The Author(s). JCSM Communications published by Wiley Periodicals LLC.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1017-236c8a1b03c5ab41ef9ad9e79b5e59d8e33da291f9eeba2a2e25b055f5a9a38f3</cites><orcidid>0000-0002-6551-1333</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Frco2.97$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Frco2.97$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,11561,27923,27924,46051,46475</link.rule.ids></links><search><creatorcontrib>Pedraza, Laura</creatorcontrib><creatorcontrib>Laosa, Olga</creatorcontrib><creatorcontrib>Segovia‐Moreno, Rocío</creatorcontrib><creatorcontrib>Alcalá, Álvaro</creatorcontrib><creatorcontrib>Tornero‐López, María Isabel</creatorcontrib><creatorcontrib>Corral‐Muñoz, Germán</creatorcontrib><creatorcontrib>López, Patricia</creatorcontrib><creatorcontrib>Carnicero, Jose Antonio</creatorcontrib><creatorcontrib>Ramirez, Maria</creatorcontrib><creatorcontrib>Camprubi, Maria</creatorcontrib><creatorcontrib>Rodríguez‐Mañas, Leocadio</creatorcontrib><title>Long‐term clinical, nutritional, and functional outcomes of COVID‐19 patients after hospital discharge</title><title>JCSM communications</title><description>Background
Long‐term nutritional and functional status after hospitalization due to COVID‐19 has been poorly described. We show the physical and nutritional stata and the symptoms compatible with Long‐COVID in patients who survived after an episode of hospitalization due to COVID‐19 and the associated factors.
Methods
Single‐center prospective observational study. Clinical, nutritional, and physical function data were assessed in 345 subjects over 18 years of age hospitalized in an university hospital for a diagnosis of COVID‐19 in 2020 at three different times of follow‐up: 6 (n = 118), 9 (n = 115), and 15 months (n = 112) after discharge. All survivors discharged during each of those periods were called consecutively at the times of follow‐up in order to collect data about their nutritional and functional stata, and long‐COVID symptoms.
Results
The mean age of the 345 subjects included in the present study was 62.8 years (SD 15.8), and 180 (52.2%) were men. The mean number of comorbidities was 2.6 (SD 2.1). After a mean follow‐up time of 10.2 ± 3.2 months, mean Barthel score showed a decrease of 2.00 (SD 0.12) points, that showed to be consistent disregarding the time after discharge (6 months: 1.71 ± 4.8; 9 months: 2.17 ± 5.97; 15 months: 2.20 ± 5.25). The risk factors associated with worsening in the Barthel index score were basal Barthel index [BI < 95; odds ratio (OR): 3.34, 95% confidence interval (CI): 1.26–8.85], age (OR: 1.03, CI: 1.00–1.06, per year), having comorbidities (≥3 pathologies) (OR: 1.98, CI: 1.00–3.90), and female sex (OR: 2.68, CI: 1.47–4.90). Self‐reported Long‐COVID symptoms were frequent, mainly those related to functioning: fatigue/tiredness (39.4%), decreased mobility (16.2%), and subjective loss of muscle mass/strength (15.9%) plus mental complaints (depression/anxiety; 20.6%). Decreased mobility (OR 7.82, CI: 3.69–16.55), cognitive impairment (OR 6.76, CI: 2.22–20.58) and a score in SARC‐F ≥ 2 (OR: 3.89; CI: 2.03–7.49) at follow‐up were associated to the worsening in BI. BMI showed a modest, non‐significant decrease at 6 months (−0.3 ± 1.7 kg/m2), that was fully recovered in the longest follow‐up period (+0.4 ± 2.1).
Conclusions
Admission for COVID‐19 produces a significant functional loose, mainly in those who are older, female, and with a poor basal functional status and comorbidities. This impairment does not recover spontaneously and is a main component of the long‐term COVID‐19 symptoms.</description><subject>COVID‐19</subject><subject>Functional status</subject><subject>Long‐COVID</subject><subject>Long‐term follow‐up</subject><subject>Nutritional status</subject><subject>Sarcopenia</subject><issn>2996-1394</issn><issn>2996-1394</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kM1KAzEcxIMoWGrxFXLzoFvz0e1ujrJ-FQoFUa_Lf7P_tCnbpCQp0puP4DP6JG6pBy-eZgZ-M4ch5JKzMWdM3AbtxVgVJ2QglJpmXKrJ6R9_TkYxrhljUgpWlOWArOfeLb8_vxKGDdWddVZDd0PdLgWbrHeHAK6lZuf0MVO_S9pvMFJvaLV4n933da7oFpJFlyIF04_RlY9bm3q8tVGvICzxgpwZ6CKOfnVI3h4fXqvnbL54mlV380xzxotMyKkugTdM6hyaCUejoFVYqCbHXLUlStmCUNwoxAYECBR5w_Lc5KBAlkYOydVxVwcfY0BTb4PdQNjXnNWHl-rDS7UqevL6SH7YDvf_YfVLtRA9_QPzdGvP</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Pedraza, Laura</creator><creator>Laosa, Olga</creator><creator>Segovia‐Moreno, Rocío</creator><creator>Alcalá, Álvaro</creator><creator>Tornero‐López, María Isabel</creator><creator>Corral‐Muñoz, Germán</creator><creator>López, Patricia</creator><creator>Carnicero, Jose Antonio</creator><creator>Ramirez, Maria</creator><creator>Camprubi, Maria</creator><creator>Rodríguez‐Mañas, Leocadio</creator><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-6551-1333</orcidid></search><sort><creationdate>202407</creationdate><title>Long‐term clinical, nutritional, and functional outcomes of COVID‐19 patients after hospital discharge</title><author>Pedraza, Laura ; Laosa, Olga ; Segovia‐Moreno, Rocío ; Alcalá, Álvaro ; Tornero‐López, María Isabel ; Corral‐Muñoz, Germán ; López, Patricia ; Carnicero, Jose Antonio ; Ramirez, Maria ; Camprubi, Maria ; Rodríguez‐Mañas, Leocadio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1017-236c8a1b03c5ab41ef9ad9e79b5e59d8e33da291f9eeba2a2e25b055f5a9a38f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>COVID‐19</topic><topic>Functional status</topic><topic>Long‐COVID</topic><topic>Long‐term follow‐up</topic><topic>Nutritional status</topic><topic>Sarcopenia</topic><toplevel>online_resources</toplevel><creatorcontrib>Pedraza, Laura</creatorcontrib><creatorcontrib>Laosa, Olga</creatorcontrib><creatorcontrib>Segovia‐Moreno, Rocío</creatorcontrib><creatorcontrib>Alcalá, Álvaro</creatorcontrib><creatorcontrib>Tornero‐López, María Isabel</creatorcontrib><creatorcontrib>Corral‐Muñoz, Germán</creatorcontrib><creatorcontrib>López, Patricia</creatorcontrib><creatorcontrib>Carnicero, Jose Antonio</creatorcontrib><creatorcontrib>Ramirez, Maria</creatorcontrib><creatorcontrib>Camprubi, Maria</creatorcontrib><creatorcontrib>Rodríguez‐Mañas, Leocadio</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Wiley Online Library Free Content</collection><collection>CrossRef</collection><jtitle>JCSM communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pedraza, Laura</au><au>Laosa, Olga</au><au>Segovia‐Moreno, Rocío</au><au>Alcalá, Álvaro</au><au>Tornero‐López, María Isabel</au><au>Corral‐Muñoz, Germán</au><au>López, Patricia</au><au>Carnicero, Jose Antonio</au><au>Ramirez, Maria</au><au>Camprubi, Maria</au><au>Rodríguez‐Mañas, Leocadio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long‐term clinical, nutritional, and functional outcomes of COVID‐19 patients after hospital discharge</atitle><jtitle>JCSM communications</jtitle><date>2024-07</date><risdate>2024</risdate><volume>7</volume><issue>2</issue><spage>99</spage><epage>106</epage><pages>99-106</pages><issn>2996-1394</issn><eissn>2996-1394</eissn><abstract>Background
Long‐term nutritional and functional status after hospitalization due to COVID‐19 has been poorly described. We show the physical and nutritional stata and the symptoms compatible with Long‐COVID in patients who survived after an episode of hospitalization due to COVID‐19 and the associated factors.
Methods
Single‐center prospective observational study. Clinical, nutritional, and physical function data were assessed in 345 subjects over 18 years of age hospitalized in an university hospital for a diagnosis of COVID‐19 in 2020 at three different times of follow‐up: 6 (n = 118), 9 (n = 115), and 15 months (n = 112) after discharge. All survivors discharged during each of those periods were called consecutively at the times of follow‐up in order to collect data about their nutritional and functional stata, and long‐COVID symptoms.
Results
The mean age of the 345 subjects included in the present study was 62.8 years (SD 15.8), and 180 (52.2%) were men. The mean number of comorbidities was 2.6 (SD 2.1). After a mean follow‐up time of 10.2 ± 3.2 months, mean Barthel score showed a decrease of 2.00 (SD 0.12) points, that showed to be consistent disregarding the time after discharge (6 months: 1.71 ± 4.8; 9 months: 2.17 ± 5.97; 15 months: 2.20 ± 5.25). The risk factors associated with worsening in the Barthel index score were basal Barthel index [BI < 95; odds ratio (OR): 3.34, 95% confidence interval (CI): 1.26–8.85], age (OR: 1.03, CI: 1.00–1.06, per year), having comorbidities (≥3 pathologies) (OR: 1.98, CI: 1.00–3.90), and female sex (OR: 2.68, CI: 1.47–4.90). Self‐reported Long‐COVID symptoms were frequent, mainly those related to functioning: fatigue/tiredness (39.4%), decreased mobility (16.2%), and subjective loss of muscle mass/strength (15.9%) plus mental complaints (depression/anxiety; 20.6%). Decreased mobility (OR 7.82, CI: 3.69–16.55), cognitive impairment (OR 6.76, CI: 2.22–20.58) and a score in SARC‐F ≥ 2 (OR: 3.89; CI: 2.03–7.49) at follow‐up were associated to the worsening in BI. BMI showed a modest, non‐significant decrease at 6 months (−0.3 ± 1.7 kg/m2), that was fully recovered in the longest follow‐up period (+0.4 ± 2.1).
Conclusions
Admission for COVID‐19 produces a significant functional loose, mainly in those who are older, female, and with a poor basal functional status and comorbidities. This impairment does not recover spontaneously and is a main component of the long‐term COVID‐19 symptoms.</abstract><doi>10.1002/rco2.97</doi><tpages>106</tpages><orcidid>https://orcid.org/0000-0002-6551-1333</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2996-1394 |
| ispartof | JCSM communications, 2024-07, Vol.7 (2), p.99-106 |
| issn | 2996-1394 2996-1394 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_rco2_97 |
| source | Open Access: Wiley-Blackwell Open Access Journals |
| subjects | COVID‐19 Functional status Long‐COVID Long‐term follow‐up Nutritional status Sarcopenia |
| title | Long‐term clinical, nutritional, and functional outcomes of COVID‐19 patients after hospital discharge |
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