Triazine‐Triazole Conjugates as Potent Ligands for Cu–Catalyzed Sonogashira Reaction

Triazine Triazole conjugates (TT) were developed as efficient ligand system for CuSO4⋅5H2O catalyzed Sonogashira and decarboxylative cross‐coupling reaction. This new protocol showed good compatibility with a broad range of substitutents and afforded moderate to excellent yields. TT ligands are rapi...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2016-03, Vol.1 (3), p.391-395
Main Authors: Wang, Zhenhua, Wang, Xiu, Sun, Huaming, Zhu, Zhuangli, Zhang, Guofang, Zhang, Weiqiang, Gao, Ziwei
Format: Article
Language:English
Subjects:
copper catalysis
CuSO4⋅5H2O
decarboxylative coupling
N ligands
Sonogashira reaction
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Summary:Triazine Triazole conjugates (TT) were developed as efficient ligand system for CuSO4⋅5H2O catalyzed Sonogashira and decarboxylative cross‐coupling reaction. This new protocol showed good compatibility with a broad range of substitutents and afforded moderate to excellent yields. TT ligands are rapid constructed and highly modular electronically and sterically. CuSO4⋅5H2O/L1 system was developed for Sonogashira and decarboxylative cross‐coupling reaction. This new protocol showed good compatibility with a broad range of substituents and afforded moderate to excellent yields. TT ligands are rapid construction structures, highly modular, easily electronically and sterically modified. It was also worth noted that both Cu(I) and Cu(II) salts were significantly accelerated by TT ligands for the cross‐coupling reaction.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201600113