Tri–tert‐Butanolamine as an Organic Promoter in Nucleophilic Fluorination

Tri‐tert‐butanol amine acts as promoter with alkali metal salts in the nucleophilic fluorination of alkylsulfonates. It significantly enhances the reactivity of alkali metal salts with minimum formation of side‐products (alkene, ether, and alcohol) compared to other catalysts in fluorination reactio...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2017-01, Vol.2 (1), p.118-122
Main Authors: Shinde, Sandip S., Khonde, Nilesh S., Kumar, Pradeep
Format: Article
Language:English
Subjects:
Fluorination
Nucleophilic Substitution
Organocatalyst
tert-Butanolamine
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Summary:Tri‐tert‐butanol amine acts as promoter with alkali metal salts in the nucleophilic fluorination of alkylsulfonates. It significantly enhances the reactivity of alkali metal salts with minimum formation of side‐products (alkene, ether, and alcohol) compared to other catalysts in fluorination reaction. The synergism of tert‐alcohol and amine moiety plays a pivotal role in fluorination. Tri‐tert‐butanol amine acts as promoter in nucleophilic fluorination with alkylsulfonates. It significantly enhances the reactivity of alkali metal fluoride compared to other catalysts including cryptand.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201601735