Neoteric Synthesis and Biological Activities of Chromenopyrazolones, Tosylchromenopyrazolones, Benzoylcoumarins

Chromenopyrazolones, tosylchromenopyrazolones and benzoylcoumarins were prepared by the reaction of salicylaldehyde tosylhydrazones with 3‐oxobutanoates. The title compounds were screened for their in vitro anti‐microbial, DPPH, ABTS.+ free radical scavenging, α‐glucosidase inhibitory and anti‐infla...

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Published in:ChemistrySelect (Weinheim) 2017-11, Vol.2 (32), p.10628-10634
Main Authors: Hariprasad, Kurma Siva, Anand, Ajay, Rathod, Balaji Baburao, Zehra, Amtul, Tiwari, Ashok Kumar, Prakasham, Reddy Shetty, Raju, Bhimapaka China
Format: Article
Language:English
Subjects:
3-Oxobutanoates
Anti-inflammatory activity
Chromenopyrazolones
Salicylaldehyde tosylhydrazones
α-Glucosidase inhibitory activity
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Summary:Chromenopyrazolones, tosylchromenopyrazolones and benzoylcoumarins were prepared by the reaction of salicylaldehyde tosylhydrazones with 3‐oxobutanoates. The title compounds were screened for their in vitro anti‐microbial, DPPH, ABTS.+ free radical scavenging, α‐glucosidase inhibitory and anti‐inflammatory activities. The bioactivity profile studies revealed that the trifluoromethyl chromenopyrazolones were effective for anti‐microbial activity. Trifluoromethyl chromenopyrazolones 5 h, 5 j, 5 l, tosyl chromenopyrazolones 5 m‐q and benzoylcoumarin 6 g are the promising α‐glucosidase inhibitors. The methyl chromenopyrazolones 5 b‐d, trifluoromethyl chromenopyrazolones 5 h‐l, tosylchromenopyrazolone 5 m and methoxy benzoylcoumarin 6 h denoted promising anti‐inflammatory activity. Chromenopyrazolones, tosylchromenopyrazolones and benzoylcoumarins were prepared by the reaction of salicylaldehyde tosylhydrazones with 3‐oxobutanoates. The title compounds were screened for their in vitro anti‐microbial, DPPH, ABTS.+ free radical scavenging, α‐glucosidase inhibitory and anti‐inflammatory activities.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201700587