A Ligand/Additive/Base‐Free C(sp2)‐H Activation and Isocyanide Insertion in PEG‐400: Synthesis of Indolizine/Imidazoline‐Fused Heterocycles

A ligand/base/metal oxidant free Pd‐catalyzed C(sp2)–H activation, followed by isocyanide insertion to synthesize indolizine/imidazoline fused heterocyclics in PEG‐400 as a recyclable solvent. The present transformation is greener and an efficient strategy using oxygen as external oxidant. The spect...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2018-05, Vol.3 (17), p.4581-4585
Main Authors: Kumar, K. Shiva, Rajesham, Bandari, Kumar, N. Praveen, Ramulu, Meesa Siddi, Dandela, Rambabu
Format: Article
Language:English
Subjects:
C−H activation
heterocycles
isocyanide insertion
PEG-400
spectroscopic properties
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Summary:A ligand/base/metal oxidant free Pd‐catalyzed C(sp2)–H activation, followed by isocyanide insertion to synthesize indolizine/imidazoline fused heterocyclics in PEG‐400 as a recyclable solvent. The present transformation is greener and an efficient strategy using oxygen as external oxidant. The spectroscopic properties of selected indolizine/imidazoline fused heterocyclics were studied by UV−visible and fluorescence spectroscopy. An efficient method for the synthesis of indolizine/imidazoline fused heterocyclics via C(sp2)–H activation, followed by isocyanide insertion in PEG‐400. This transformation is a ligand/base/metal oxidant free and affording the desired products in good yields. The UV−vis absorption and fluorescence spectra of some products were measured to study their photophysical properties.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201800397