A Novel and Efficient Methodology for the Synthesis of Vinylamide Derivatives Using [Ce(L‐Pro)2]2Ox as Heterogeneous Catalyst

• Published in: ChemistrySelect (Weinheim) 2018-06, Vol.3 (23), p.6570-6574
• Main Authors: Tavares Junior, José M. C., Silva, Caren D. G., dos Santos, Beatriz F., da Silva, Beatriz A. L., de Oliveira, Aline R., Kupfer, Vicente L., Rinaldi, Andrelson W., Domingues, Nelson Luís C.
• Format: Article
• Language: English
• Subjects: arylvinylbenzamides; azlactones; cerium; heterogeneous catalysis
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.201800760

In this work, we presented a simple, efficient, scalable, and green methodology for the synthesis of arylvinylbenzamides using various anilines and azlactones with [Ce(L‐Pro)2]2Ox as heterogeneous catalyst under green conditions in a short reaction time obtained good to excellent yields. In this work we propose a new, regioselective, scalable and efficient synthesis of arylvinylbenzamides using[Ce(L‐Pro)2]2Ox as heterogeneous catalyst under green conditions aiming to obtain an efficient route for potentially interesting compounds. The synthesis of arylvinylbenzamides was successfully obtained affording a series of compounds with good to excellent yields. A scale‐up synthesis was performed with good yield indicating that the procedure can be applied to industrial processes.