Water‐PEG‐400 Mediated an Efficient One‐Pot Eco‐Friendly Synthesis of Functionalized Isoxazole Substituted Chromeno[2, 3‐b]pyridine‐3‐carboxylate Derivatives

A green, straightforward, and efficient protocol for the synthesis of a new series of isoxazolyl chromeno[2, 3‐b]pyridine‐3‐carboxylate derivatives have been reported by one‐pot reaction of isoxazolyl enamino esters and 3‐formylchromones by employing water as a reaction medium and polyethylene glyco...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2018-07, Vol.3 (27), p.7766-7770
Main Authors: Ponduri, Rajasekhar, Kumar, Pramod, Vadali, Lakshmana RAO, Modugu, Nagi Reddy
Format: Article
Language:English
Subjects:
Green chemistry
Isoxazolyl chromeno[2,3-b]pyridine
One-pot synthesis
PEG-400
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Summary:A green, straightforward, and efficient protocol for the synthesis of a new series of isoxazolyl chromeno[2, 3‐b]pyridine‐3‐carboxylate derivatives have been reported by one‐pot reaction of isoxazolyl enamino esters and 3‐formylchromones by employing water as a reaction medium and polyethylene glycol‐400 (PEG‐400) as the green promoter. The superiority of this protocol is environmentally benign, simple operation, metal‐free, broad substrate scope, good yields, less reaction time and PEG‐400 can be recovered and reused. Most significant of all, this protocol is green. An efficient method for the synthesis of isoxazolyl chromeno[2, 3‐b]pyridine‐3‐carboxylates from isoxazolyl enamino esters and 3‐formylchromones by employing water as a reaction medium and PEG‐400 as the only green promoter.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201801089