Biological Activity of New Cyclophosphazene Derivatives Including Fluorenylidene‐Bridged Cyclophosphazenes

In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, 1H, 31P NMR techniques. Later, the effects of the synthesized comp...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2018-09, Vol.3 (34), p.9933-9939
Main Authors: Yıldırım, Tuba, Şenkuytu, Elif, Ergene, Emel, Bilgin, Kemal, Uludağ, Yıldız, Çiftçi, Gönül Yenilmez
Format: Article
Language:English
Subjects:
Biological Activity
Cyclophosphazene
DNA Binding
Fluorenylidene
Phosphazene
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Summary:In this study, new cyclophosphazene compounds were synthesized characterized and their biological activity studies were performed. The structural investigations of the compounds were verified by elemental analyses, mass spectrometry, 1H, 31P NMR techniques. Later, the effects of the synthesized compounds to DNA were screened using DNA interaction analysis and cleavage methods by utilizing pUC18 plasmid. The results showed that the compounds 14, 40 and 45 caused Form III (linearized DNA) plasmid DNA, indicating the interaction of these compounds with the plasmid DNA. In this study, new cyclophosphazene compounds were synthesized and characterized. The biological activity studies of the newly and previously synthesized compounds were carried out. The antimicrobial susceptibility tests showed that the synthesized cyclophosphazene compounds have antibacterial activity. The effects of the synthesized compounds to DNA were screened using DNA interaction analysis. Some compounds have shown DNA binding properties.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201801766