Hybrid Oleic Acid‐Graphene Quantum Dot Vesicles for Drug Delivery

• Published in: ChemistrySelect (Weinheim) 2019-04, Vol.4 (14), p.4347-4354
• Main Authors: Boruah, Jayanta S., Chowdhury, Devasish
• Format: Article
• Language: English
• Subjects: Drug delivery system; Graphene quantum dot; Vesicles
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.201803619

Bio‐mimicking hybrid vesicle systems are ideal candidates for drug/gene delivery and nano‐reactor applications. Here, we report the fabrication of hybrid oleic acid‐graphene quantum dot vesicles that were successfully used as an efficient drug delivery system (DDS). The fabricated hybrid oleic acid‐graphene quantum dot vesicles were characterized by UV‐Visible spectrophotometry, optical microscopy, dynamic light scattering and scanning electron microscopy. In this experiment, methylene blue (MB) dye was used as a model drug. Hybrid oleic acid‐graphene quantum dot vesicles were very efficient in drug loading (98.3%) when compared with bare oleic acid vesicles (71.98%). It is observed that drug release was pH‐dependent and higher release was observed at pH 5, much lower or negligible release takes place at pH 7.4. Development of such hybrid vesicles will lead to biocompatible, nontoxic, easily fabricated, and stimuli responsive DDSs. A novel nanohybrid oleic acid‐graphene quantum dot (OA‐GQD) vesicle system was prepared with efficient drug loading and pH dependent drug release ability. Here, we studied the drug loading and release taking methylene blue as model drug. It was observed that the fabricated hybrid system is efficient in terms of drug loading (98.3%) than that of bare oleic acid vesicles (71.98%). Interestingly, it releases drug only at pH 5 and negligible release is found at pH 7.4.