The Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β‐Ketoamides

A method for the synthesis of isocytosine analogs from β‐ketoamides was investigated. Application of the method to β‐ketoamides including a 2‐cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 examples of pyrimidone derivatives were synthesized in dif...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2021-03, Vol.6 (12), p.2919-2922
Main Authors: Üngören, Ş. Hakan, Öztürk, Merve, Değerli, E. Aysel
Format: Article
Language:English
Subjects:
cascade reaction
cyanamide
pyrimidin-4(3H)-one
pyrimido[1,2-a]quinazolin-1-one
β-Ketoamides
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Summary:A method for the synthesis of isocytosine analogs from β‐ketoamides was investigated. Application of the method to β‐ketoamides including a 2‐cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 examples of pyrimidone derivatives were synthesized in different patterns. The method allows the synthesis of 3‐substituted 2‐aminopyrimidin‐4(3H)‐one and 6‐amino‐1H‐pyrimido[1,2‐a]quinazolin‐1‐one heterocyclic systems, which are previously undefined hetero‐skeletons.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202100203