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The Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β‐Ketoamides
A method for the synthesis of isocytosine analogs from β‐ketoamides was investigated. Application of the method to β‐ketoamides including a 2‐cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 examples of pyrimidone derivatives were synthesized in dif...
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Published in: | ChemistrySelect (Weinheim) 2021-03, Vol.6 (12), p.2919-2922 |
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creator | Üngören, Ş. Hakan Öztürk, Merve Değerli, E. Aysel |
description | A method for the synthesis of isocytosine analogs from β‐ketoamides was investigated. Application of the method to β‐ketoamides including a 2‐cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 examples of pyrimidone derivatives were synthesized in different patterns.
The method allows the synthesis of 3‐substituted 2‐aminopyrimidin‐4(3H)‐one and 6‐amino‐1H‐pyrimido[1,2‐a]quinazolin‐1‐one heterocyclic systems, which are previously undefined hetero‐skeletons. |
doi_str_mv | 10.1002/slct.202100203 |
format | article |
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The method allows the synthesis of 3‐substituted 2‐aminopyrimidin‐4(3H)‐one and 6‐amino‐1H‐pyrimido[1,2‐a]quinazolin‐1‐one heterocyclic systems, which are previously undefined hetero‐skeletons.</description><subject>cascade reaction</subject><subject>cyanamide</subject><subject>pyrimidin-4(3H)-one</subject><subject>pyrimido[1,2-a]quinazolin-1-one</subject><subject>β-Ketoamides</subject><issn>2365-6549</issn><issn>2365-6549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqFkEtOwzAQhi0EElXplrUvkOJHkzjsUEShoqgCyjqajB1qlMYodlWFFUfgLByEQ3ASWhXxWKFZzMyv-WbxEXLM2ZAzJk58jWEomNguTO6RnpBJHCXxKNv_NR-SgfePjDGeqETEaY-s5wtDr12wladV65Z04h12wXnbGAqNpuOVN_pPurZhQW9WtoFnV2-CUzprH6BxCAHqLlikOXgEbeitAQzWNdRV9P3t4-X1ygQHS6uNPyIHFdTeDL56n9yPz-f5ZTSdXUzys2mEQmUyKtEojGPIOIcSJEpRZahKoY0UUqSpSDalVYpasEoqVBzLODFQZtrESo1knwx3f7F13remKp5au4S2KzgrtrKKrbni29wGyHbA2tam--e6uJvm8x_2E9B9dqE</recordid><startdate>20210326</startdate><enddate>20210326</enddate><creator>Üngören, Ş. Hakan</creator><creator>Öztürk, Merve</creator><creator>Değerli, E. Aysel</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5272-4241</orcidid></search><sort><creationdate>20210326</creationdate><title>The Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β‐Ketoamides</title><author>Üngören, Ş. Hakan ; Öztürk, Merve ; Değerli, E. Aysel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2893-bce8c55a911aba3c32f9c8b2de32327726262d87cd20f38c81cb56eab9de58843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>cascade reaction</topic><topic>cyanamide</topic><topic>pyrimidin-4(3H)-one</topic><topic>pyrimido[1,2-a]quinazolin-1-one</topic><topic>β-Ketoamides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Üngören, Ş. Hakan</creatorcontrib><creatorcontrib>Öztürk, Merve</creatorcontrib><creatorcontrib>Değerli, E. Aysel</creatorcontrib><collection>CrossRef</collection><jtitle>ChemistrySelect (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Üngören, Ş. Hakan</au><au>Öztürk, Merve</au><au>Değerli, E. Aysel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β‐Ketoamides</atitle><jtitle>ChemistrySelect (Weinheim)</jtitle><date>2021-03-26</date><risdate>2021</risdate><volume>6</volume><issue>12</issue><spage>2919</spage><epage>2922</epage><pages>2919-2922</pages><issn>2365-6549</issn><eissn>2365-6549</eissn><abstract>A method for the synthesis of isocytosine analogs from β‐ketoamides was investigated. Application of the method to β‐ketoamides including a 2‐cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 examples of pyrimidone derivatives were synthesized in different patterns.
The method allows the synthesis of 3‐substituted 2‐aminopyrimidin‐4(3H)‐one and 6‐amino‐1H‐pyrimido[1,2‐a]quinazolin‐1‐one heterocyclic systems, which are previously undefined hetero‐skeletons.</abstract><doi>10.1002/slct.202100203</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-5272-4241</orcidid></addata></record> |
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subjects | cascade reaction cyanamide pyrimidin-4(3H)-one pyrimido[1,2-a]quinazolin-1-one β-Ketoamides |
title | The Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β‐Ketoamides |
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