Phosphine‐Free Ruthenium Complex for Hydrogenation of Carbonyl Compounds: Synthesis and Applications

A new phosphine‐free Ruthenium complex bearing hemilabile thiophene‐based ligand is synthesized for the large‐scale catalytic hydrogenation of carbonyl compounds. The methodology is also applicable for the one‐pot synthesis of various benzhydryl active pharmaceutical ingredients (APIs). A highly eff...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2021-08, Vol.6 (32), p.8411-8415
Main Authors: Shashikumar, K., Maldode, Suraj B., Sajjanar, Sachinkumar, Hegde, Shivaprasad N., Sattineni, Suribabu, Avasare, Vidya D., Gadakh, Amol V., Ganesh, Sambasivam, Sathiyanarayanan, A. M.
Format: Article
Language:English
Subjects:
Benzhydrols
Hemilabile ligands
Homogenous hydrogenation
Ruthenium catalysis
Thiophene-based ligands
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Summary:A new phosphine‐free Ruthenium complex bearing hemilabile thiophene‐based ligand is synthesized for the large‐scale catalytic hydrogenation of carbonyl compounds. The methodology is also applicable for the one‐pot synthesis of various benzhydryl active pharmaceutical ingredients (APIs). A highly efficient, economically viable, bench stable, new phosphine‐free Ruthenium complex bearing hemilabile thiophene‐based ligand has been developed. Ru‐Complex forms an active catalyst in the presence of NHC‐ligand, in situ and widely applicable for the multi‐gram scale catalytic hydrogenation of various carbonyl compounds. The methodology is also applicable for the one‐pot synthesis of various benzhydrol active pharmaceutical ingredients (APIs). A detailed DFT study has been carried out for mechanistic understanding. The robustness of the methodology developed makes the study more attractive from the industrial point of view.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202101775