Design and Synthesis of Metastable 4H‐3,1‐Benzoxazin‐4‐one and 3‐aminoquinazoline‐4(3H)‐one for Detecting Cations in Water Samples and Agricultural Crops

The behaviour of 2‐benzyl‐4H‐3,1‐benzoxazin‐4‐one towards nitrogen nucleophiles namely, amino acids, aromatic amines, sodium azide, and secondary amines has been investigated. Also the reaction of 3‐amino‐2‐benzylquinazolin‐4(3H)‐one and 2‐[2‐benzyl‐4‐oxoquinazolin‐3(4H)‐yl]acetohydrazide with carbo...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2021-08, Vol.6 (31), p.7873-7879
Main Authors: Algohary, Ayman M., Elamin, Manahil B., Ahmed, Amani H., El‐Hashash, Maher A., Radwan, Tasnim M.
Format: Article
Language:English
Subjects:
Chemosensor
Chromium
Detection
Mercury
Quinazolinones
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Summary:The behaviour of 2‐benzyl‐4H‐3,1‐benzoxazin‐4‐one towards nitrogen nucleophiles namely, amino acids, aromatic amines, sodium azide, and secondary amines has been investigated. Also the reaction of 3‐amino‐2‐benzylquinazolin‐4(3H)‐one and 2‐[2‐benzyl‐4‐oxoquinazolin‐3(4H)‐yl]acetohydrazide with carbon electrophiles has been discussed. As well as The novel synthesized compounds were evaluated as chemosensor for detecting formyl, carbonyl group and revealed high‐selectivity and specificity to detect metals ions in water samples and, agricultural crops. Qualitative and quantitative assays indicated appreciable selectivity of novel compounds 13 and 15 as a chemo sensor for Optical detection of Hg2+and Cr2+ respectively. Colorimetric techniques are the most favourable detecting methods due to their low cost, lack of equipment, rapid and its naked eye noteworthy. Here, we designed and synthesized colorimetric chemosensors 13, 15 by the reaction of hydrazine derivative 1c with acetylacetone and ethylacetoacetate. The novel chemosensors 13 and 15 demonstrated high‐selectivity and specificity to detect Hg2+ and Cr2+ ions in water samples and, agricultural crops.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202101780