An Alkoxy Modified N‐Heterocyclic Carbene‐Palladacycle: Synthesis, Characterization and Application towards Buchwald‐Hartwig and Suzuki‐Miyaura Coupling Reactions

A well‐defined N‐heterocyclic carbene‐palladacycles (NHC‐Pdcycle) by introducing alkoxy group was synthesized, and its structure was confirmed using single‐crystal X‐ray diffraction. The complex as catalyst exhibited high catalytic activity in Buchwald‐Hartwig and Suzuki‐Miyaura coupling reactions i...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2021-10, Vol.6 (38), p.10121-10126
Main Authors: Zuo, Bin, Shao, Han, Qu, Erdong, Ma, Yunhua, Li, Wanfang, Huang, Mingxian, Deng, Qinyue
Format: Article
Language:English
Subjects:
Alkoxy group
Buchwald-Hartwig
Cross-coupling
N-heterocyclic carbene-palladacycle
Suzuki-Miyaura
Synthetic methods
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Summary:A well‐defined N‐heterocyclic carbene‐palladacycles (NHC‐Pdcycle) by introducing alkoxy group was synthesized, and its structure was confirmed using single‐crystal X‐ray diffraction. The complex as catalyst exhibited high catalytic activity in Buchwald‐Hartwig and Suzuki‐Miyaura coupling reactions involving (hetero)aryl chlorides. Remarkably, the protocol with a wide range of substrate compatibility is suitable for the gram‐scale synthesis of Piribedil, a clinical drug for the treatment of Parkinson's disease, highlighting its potential applications in pharmaceutical synthesis. The well‐defined N‐heterocyclic carbene‐palladacycles by introducing alkoxy group as efficient catalysts for Buchwald‐Hartwig and Suzuki‐Miyaura coupling reactions involving (hetero)aryl chlorides. Remarkably, the protocol with a wide range of substrate compatibility is suitable for the gram‐scale synthesis of Piribedil, a clinical drug for the treatment of Parkinson's disease, highlighting its potential applications in pharmaceutical synthesis.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202102733