A Mechanistic Approach on the Cs 2 CO 3 Mediated Synthesis of 4‐Azaindole Analogues Bearing Pyridine‐3‐Carboxamide and 1‐Phenylethanone

cesium carbonate mediated synthesis of desired 1 N‐substituted phenylethanone analogue of 4‐azaindole is carried out in Dimethylformamide. Further formation of derivatives of 6 is produced from desired analogue of 4‐azaindole. The mechanistic pathway is analyzed with density functional theory calcul...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2022-06, Vol.7 (21)
Main Authors: Atchuta Ramarao, T., Jha, Anjali, Sen, Anik
Format: Article
Language:English
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Summary:cesium carbonate mediated synthesis of desired 1 N‐substituted phenylethanone analogue of 4‐azaindole is carried out in Dimethylformamide. Further formation of derivatives of 6 is produced from desired analogue of 4‐azaindole. The mechanistic pathway is analyzed with density functional theory calculations which supported the experimental results. Due to structural similarity of azaindole core nucleus with purine ring of ATP, it is a promising /attractive molecule to be explored for its biological potential.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202200719