Synthesis and Antimicrobial Activity of Carbene Complexesof the Imidazole, Benzimidazole and 1,2,4‐Triazole Series

New carbene complexes of copper (I), silver and palladium, including ionic carbene‐phenanthroline complexes, were synthesized on the basis of imidazole, benzimidazole, 1,2,4‐triazole systems with cetyl and aryl including fluorophenyl substituents. The study of the antimicrobial action of the synthes...

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Published in:ChemistrySelect (Weinheim) 2023-03, Vol.8 (9), p.n/a
Main Authors: Rayenko, Gennady F., Avksentiev, Alexandr S., Saberov, Vagiz Sh, Rusanov, Eduard B., Ryabitsky, Alexey B., Shishkina, Svetlana V., Komarovska‐Porokhnyavets, Olena Z., Lubenets, Vira I., Korotkikh, Nikolai I.
Format: Article
Language:English
Subjects:
antimicrobial activities
antimicrobial activity
carbene complexes
cetyl
copper(I)
fluorine
palladium
phenanthroline-containing metal carbene complexes
synthesis
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Summary:New carbene complexes of copper (I), silver and palladium, including ionic carbene‐phenanthroline complexes, were synthesized on the basis of imidazole, benzimidazole, 1,2,4‐triazole systems with cetyl and aryl including fluorophenyl substituents. The study of the antimicrobial action of the synthesized compounds revealed high antibacterial and antifungal activities of fluoro‐ and phenanthroline‐containing carbene complexes. New cetyl‐, fluoro‐, pyridine‐ and phenanthroline‐containing carbene complexes of copper (I), silver and palladium were synthesized to search for new biologically active compounds. Ionic copper (I) carbene‐phenanthroline complex of type II exhibits high antibacterial activity. Fluorine‐containing silver complexes of type I, ionic compounds II and o‐phenanthroline also show high antifungal effects.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202203143