Current Status of Natural Products/siRNA Co‐Delivery for Cancer Therapy

siRNA interference is a conserved cellular gene silencing mechanism and a viable technique for human disease intervention, including cancer. This method has significant potential benefits over currently available treatments. The limitations of using siRNA‐based systems are the lack of specificity, h...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2022-11, Vol.7 (44), p.n/a
Main Authors: Jacob, Megha Mariya, Santhosh, Amritha, Rajeev, Anjaly, Joy, Reshma, John, Pooja Mary, John, Franklin, George, Jinu
Format: Article
Language:English
Subjects:
anticancer therapy
co-delivery platforms
nanocarriers
natural products
small interfering RNA
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Summary:siRNA interference is a conserved cellular gene silencing mechanism and a viable technique for human disease intervention, including cancer. This method has significant potential benefits over currently available treatments. The limitations of using siRNA‐based systems are the lack of specificity, high chance of degradation, toxicity, and ineffective cellular uptake. Combination therapy using natural compounds possesses higher therapeutical value with siRNA. Various natural compounds are used in cancer treatments such as paclitaxel, ursolic acid, hypericin, etoposide, etc due to their diverse bioactivities. In this review, the codelivery of natural compounds/siRNA using nanovehicles is highlighted. This review emphasis on the co‐delivery of natural compounds which possess higher therapeutical value with siRNA using nanovehicles. The efficiency of nanocarrier vehicles for siRNA /natural compounds co‐delivery and the benefits of combination treatments are also explored. The significant potential benefits of this method over currently known cancer treatments are also explained.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202203476