Synthesis of Six New Transition Metal Complexes: Structural Characterization and in vitro α‐Glucosidase Inhibitions Studies

• Published in: ChemistrySelect (Weinheim) 2023-03, Vol.8 (11), p.n/a
• Main Authors: Azeem Shakil, Muhammad, Ullah, Saeed, Raza Shah, Syed, Al‐Harrasi, Rashid, Khan, Ajmal, Al‐Harrasi, Ahmed, Anwar, Muhammad U., Powell, Annie K.
• Format: Article
• Language: English
• Subjects: in situ ligand synthesis; nitriles; single crystal diffraction; transition metal complexes; α-glucosidase Inhibitions
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202204040

Three one‐pot reactions leading to six new transition metal complexes are presented. The one‐pot reactions involved transformations of 2‐(N’‐dicyanomethylene‐hydrazino)‐benzoic acid (DHB) into three new ligands (Lig‐I)2−, (Lig‐II)2−, and (Lig‐III)2−. The complex [Ni2(Lig‐I)2] ⋅ 3H2O (1) was prepared in a one‐pot synthesis in which ligand, (Lig‐I)2− was formed by the amination of DHB resulting from the nucleophilic attack of an amino group of ethylenediamine (en). The complex [Cu(Lig‐II)(en)(H2O)] (2) was prepared in a one‐pot synthesis in which ligand, (Lig‐II)2− was formed by the nucleophilic attack of an amino group of en resulting in an imidazole ring formation. The dinunclear complexes [Zn2(Lig‐III)2(CH3OH)2] (3) and [Cu2(Lig‐III)2(CH3OH)2] (4), a linear trinuclear complex [Ni3(Lig‐III)(en)2(CH3OH)] (5), and a mononuclear complex [Mn(Lig‐III)(CH3OH)4] (6) were synthesized using a preparation involving conversion of one of the nitriles on DHB into an imino‐ester. The resulting complexes were characterized using a variety of analytical techniques including infra‐red and UV‐vis spectroscopy, elemental analysis, and single‐crystal X‐ray diffraction analysis. The complexes displayed α‐glucosidase enzyme inhibition with IC50 values in the range of 1.57–207 μM. In this study, we have synthesized six new first‐row transition metal complexes using one‐pot processes that include in situ generation of new aryl hydrazone ligands. We demonstrated that in situ ligand formations can be a useful tool for the self‐assembly of novel coordination compounds. The complexes displayed α‐glucosidase enzyme inhibition with IC50 values in the range of 1.57–207 μM.