Insights into 4,4′‐Arylmethylene‐Bis‐1 H ‐Pyrazol‐5‐Ols Scaffolds: Various Synthetic Routes and Their Applications

Pyrazole and its derivatives have grown in prominence over the past three decades due to their remarkable therapeutic effects and robust pharmacological potency. This review exclusively focused on synthesis of 4,4’‐arylmethylene‐bis‐1 H ‐pyrazol‐5‐ols scaffolds owing to their diversified application...

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Published in:ChemistrySelect (Weinheim) 2023-01, Vol.8 (4)
Main Authors: Kanagare, Anant B., Yadav, M.Sc.Ashok R., Katariya, Ashishkumar P., Bhagat, Devidas S., Dhas, Ajit K., Pansare, Dattatraya N., Nagwade, Pratik A., Kumar, Brajesh, Sangshetti, Jaiprakash N., Deshmukh, Satish U.
Format: Article
Language:English
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Summary:Pyrazole and its derivatives have grown in prominence over the past three decades due to their remarkable therapeutic effects and robust pharmacological potency. This review exclusively focused on synthesis of 4,4’‐arylmethylene‐bis‐1 H ‐pyrazol‐5‐ols scaffolds owing to their diversified applications along with C−C multiple bond formations in a one step. Last twenty years, more than ninety synthetic methodologies have been developed because of these motifs′ advanced applicability, which prompted researchers to study this molecule. We focused on this synthesis advancement till the last quarter of the year 2022 which summarizes all results of MCRs obtained in conventional and non‐conventional media. It will serve as a key role for synthetic organic chemists working in this field.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202204088