Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

• Published in: ChemistrySelect (Weinheim) 2023-05, Vol.8 (19), p.n/a
• Main Authors: Jeelan Basha, N., Chandana, T. L.
• Format: Article
• Language: English
• Subjects: Antiviral drugs; Pathogenesis; Pyrimidines; Viral Infection; Viral pathways
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202205009

To date, viruses are known to cause chronic to acute pathogenesis. Nevertheless, antiviral drugs have been known for their medicinal applications for the last few decades to treat infections caused by these pathogens. Despite advancements in the field of vaccination and antiviral drugs, there is a need for a molecule that can eradicate or control viral infection without getting resistance from pathogens will be a real challenge. This review covers possible ways to treat viral infections with pyrimidine and its mimics compared to known antiviral drugs. A comprehensive study of the report accomplished synthetic routes of pyrimidine analogs and their target‐specific antiviral potential. The present review article covers literature from 2018 to 2022. Due to the emerging threat of viral infection caused by the viruses such as HIV, HCV, Cytomegalovirus, and SARS‐CoV2, there is a need for small molecules that can eradicate these pathogens. Pyrimidines, basically nucleosides, have been known for their antiviral potential. There are challenges for the medicinal chemist to design and synthesize pyrimidine analogs specifically non‐nucleosides, as potent antiviral agents to overcome problems such as toxicity and drug resistance. This review focuses the recent reports on potent pyrimidines as antiviral