Metal‐Free Oxidative Cross‐Dehydrogenative Coupling of Alkenes with Thiophenols

A novel transition‐metal‐free regioselective allylic C−H thiolation of alkenes has been achieved by cross‐dehydrogenative coupling strategy. The present protocol realizes efficient and highly regio‐ and stereo‐selective functionalization of allylic C−H bonds under metal‐free conditions, leading to a...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2023-05, Vol.8 (20), p.n/a
Main Authors: Li, Chunsheng, Liao, Mingjian, He, Zhiquan, Chen, Yunbing, Mai, Jingna, Dong, Rui, Chen, Junhua, Chen, Lianfen
Format: Article
Language:English
Subjects:
Allylic sulfides
Cross-Dehydrogenative Coupling
Metal-Free
Radical addition
Regioselective
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Summary:A novel transition‐metal‐free regioselective allylic C−H thiolation of alkenes has been achieved by cross‐dehydrogenative coupling strategy. The present protocol realizes efficient and highly regio‐ and stereo‐selective functionalization of allylic C−H bonds under metal‐free conditions, leading to a series of allylic thioethers in good to excellent yields. Moreover, this work features mild reaction conditions, high step‐ and atom‐economy and good functional group tolerance. An efficient approach for the synthesis of allylic sulfides was developed. This metal‐free oxidative cross‐dehydrogenative coupling reaction features the advantages of high step and atom economic, broad substrates scope and excellent functional groups tolerance.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202300845