Ag‐Catalyzed, Selectfluor‐Mediated External Acid‐Free Minisci Reaction in Aqueous Solution

A silver‐catalyzed Minisci‐type reaction is reported here. Alkylation of electron‐deficient N‐heterocycles is achieved in aqueous solution through decarboxylative cross‐coupling of aliphatic acids and N‐heteroarenes in open air without external Brønsted acid. Selectfluor is used as a mild oxidant. D...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2023-05, Vol.8 (18), p.n/a
Main Authors: Wang, Wengui, Song, Yingyue, Xing, Shuya, Li, Jinfeng, Feng, Wei, Qu, Xudong, Wang, Shoufeng
Format: Article
Language:English
Subjects:
Ag-catalyzed
aqueous solution
heterocycles
Minisci reaction
radical
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Summary:A silver‐catalyzed Minisci‐type reaction is reported here. Alkylation of electron‐deficient N‐heterocycles is achieved in aqueous solution through decarboxylative cross‐coupling of aliphatic acids and N‐heteroarenes in open air without external Brønsted acid. Selectfluor is used as a mild oxidant. Different substituents on heterocycles and acids are tolerated. Primary and secondary alkyl could be introduced efficiently into the heteroarenes. A silver‐catalyzed Minisci‐type decarboxylative alkylation of electron‐deficient N‐heteroarenes in aqueous solution was reported. Selectfluor was used as the oxidant and no external acid was needed.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202300958