Ruthenium‐Catalyzed Synthesis of Macrocyclic Isoquinolines and Isoquinolones via a C−H/N−H Annulations Reaction

An Ru(II)‐catalyzed C−H annulations of oximes and N‐methoxybenzamides with bridged alkyne is described. This method is useful for the efficient synthesis of various macrocyclic isoquinolines and isoquinolones in good to moderate yields. A possible mechanism, involving a key five‐membered metallacycl...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2023-08, Vol.8 (32), p.n/a
Main Authors: Gurumurthy, Palanivelu, Raja, Rajini, Arumugam, Natarajan, Almansour, Abdulrahman I., Kumar, Raju Suresh, Perumal, Karthikeyan, Parthasarathy, Kanniyappan
Format: Article
Language:English
Subjects:
bridged alkynes
C−H annulation
isoquinoline and isoquinolone
Macrocyclic
Ru-catalyst
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Summary:An Ru(II)‐catalyzed C−H annulations of oximes and N‐methoxybenzamides with bridged alkyne is described. This method is useful for the efficient synthesis of various macrocyclic isoquinolines and isoquinolones in good to moderate yields. A possible mechanism, involving a key five‐membered metallacycle intermediate, alkyne insertion followed by reductive elimination to give a final annulated product has been proposed. We have developed a mild and efficient Ru(II)‐catalyzed C−H annulations of oximes, N‐methoxybenzamides with bridged alkyne for the synthesis of macrocyclic isoquinolines and isoquinolones in good to moderate yields.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202301735