Diversification Via Coupling Reactions and Biological Activities of Pyrimidine Derivatives

Pyrimidine derivatives have attracted much attention in medicinal chemistry because of their diversified biological properties and potential therapeutic applications. The Suzuki‐Miyaura, Sonogashira, and Buchwald‐Hartwig coupling reactions provide flexible methods for synthesizing structurally diver...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2023-12, Vol.8 (47), p.n/a
Main Authors: Ullah, Arif, Shah Bukhari, Kareem, Khan, Shahab, Farooq, Faiza, Wahab, Abdul, Hussain, Tanveer, Saleem, Sania, Babar, Natasha
Format: Article
Language:English
Subjects:
Chemical Synthetic Techniques
Molecular Modification
Pharmacological Activities
Sonogashira
Suzuki-Miyaura
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Summary:Pyrimidine derivatives have attracted much attention in medicinal chemistry because of their diversified biological properties and potential therapeutic applications. The Suzuki‐Miyaura, Sonogashira, and Buchwald‐Hartwig coupling reactions provide flexible methods for synthesizing structurally diverse pyrimidine derivatives. These reactions can modify the pyrimidine structure to incorporate different functional groups and substitution patterns, improving the pharmacological activities and maximizing the drug‐like properties. Using other coupling partners, such as aryl and heteroaryl moieties, has produced novel pyrimidine‐based scaffolds with enhanced bioactivity profiles. This comprehensive review examines the biological activities of pyrimidine derivatives, concentrating on how their diversification via coupling reactions utilizing synthetic techniques has affected their pharmacological properties. Investigating various biological effects and exploring novel artificial techniques present great opportunities for creating next‐generation medicines with improved efficacy and selectivity. This comprehensive review investigates important organic coupling reactions such as Suzuki‐Miyaura, Sonogashira, and Buchwald‐Hartwig coupling reaction, their reaction conditions, and proposed products. Also, the authors try to investigate the catalytic effect of various catalysts used in daily life chemistry. The biological potentials diversified pyrimidine derivatives are briefly discussed here. As a potential organic reaction, the Suzuki‐Miyaura, Sonogashira, and Buchwald reactions are also compared regarding reaction conditions, percent yield, catalysts, major productions, and required temperature.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202303072