Application of eco‐friendly disposable pencil graphite sensor for electrochemical evaluation and determination of podophyllotoxin using in cancer treatment

A sensitive, simple and selective voltammetric method was developed for the quantification of plant‐derived podophyllotoxin, which is included in antineoplastic drugs, using a disposable pencil graphite electrode. Using the square‐wave voltammetry technique, podophyllotoxin gave a very good voltamme...

Full description

Saved in:
Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2024-03, Vol.9 (9), p.n/a
Main Authors: Özer, Mehmet, Levent, Abdulkadir
Format: Article
Language:English
Subjects:
Anti-cancer
Pencil graphite electrode
Podophyllotoxin
Voltammetry
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A sensitive, simple and selective voltammetric method was developed for the quantification of plant‐derived podophyllotoxin, which is included in antineoplastic drugs, using a disposable pencil graphite electrode. Using the square‐wave voltammetry technique, podophyllotoxin gave a very good voltammetric response at +1.24 V (vs. Ag/AgCl) potential (at 0.0 V and after 60 s pre‐concentration) in Britton Robinson (pH 4.0) media. This procedure was used to detection the compound in the concentration range of 12.4–299.5 nM with a limit of detection to 2.62 nM (1.08 μg L−1). The proposed method has been successfully applied to human urine samples. In this study, the quantification and electrochemical properties of podophyllotoxin used in cancer treatment can be performed using a disposable pencil graphite electrode. There is a linear correlation between anodic current and concentration at +1.24 V in the range of 12.4 to 299.5 nM podophyllotoxin concentration on the disposable sensor. The developed electroanalytical method can be successfully applied to urine samples.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202305100