Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission

The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and to explore the sedative impacts of the compound by using in vivo and in silico investigations. ABR (5 and 10 mg k−1g, i.p.) and diazepam (DZP) (2 mg k−1g, i.p.) were administered to the e...

Full description

Saved in:
Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2024-10, Vol.9 (37), p.n/a
Main Authors: Ferdous, Jannatul, Bhuia, Md. Shimul, Chowdhury, Raihan, Sheikh, Salehin, Ansari, Siddique Akber, Bappi, Mehedi Hasan, Islam, Muhammad Torequl
Format: Article
Language:English
Subjects:
Abrine
GABAergic pathway
Insomnia
Molecular docking
Sedation
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and to explore the sedative impacts of the compound by using in vivo and in silico investigations. ABR (5 and 10 mg k−1g, i.p.) and diazepam (DZP) (2 mg k−1g, i.p.) were administered to the experimental animals either single or combined. TS (20 mg k−1g, i.p.) was administered to induce sleep, and latency with sleeping duration was observed for 3 h. The in silico investigation was conducted to predict the role of ABR in the gamma‐aminobutyric acid A (GABAA) receptor in the sleeping process and to evaluate pharmacokinetics and toxicity. Results showed that ABR (10 mg k−1g) significantly (p 
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202403725