β‐Cyclodextrin‐SO 3 H as a Supramolecular Catalyst for Efficient Greener Synthesis of Substituted Bis(6‐aminouracil‐5‐yl)methanes in Water

A simple, straightforward, and highly efficient greener approach for synthesizing bis(6‐aminouracil‐5‐yl)methane derivatives was developed by employing β‐cyclodextrin‐SO 3 H as supramolecular catalyst in water at 100 °C. A total of 16 bis(6‐aminouracil‐5‐yl)methanes were synthesized via a one‐pot re...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2024-11, Vol.9 (42)
Main Authors: Gosavi, Swati D., Kale, Arun D., Dalal, Dipak S.
Format: Article
Language:English
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Summary:A simple, straightforward, and highly efficient greener approach for synthesizing bis(6‐aminouracil‐5‐yl)methane derivatives was developed by employing β‐cyclodextrin‐SO 3 H as supramolecular catalyst in water at 100 °C. A total of 16 bis(6‐aminouracil‐5‐yl)methanes were synthesized via a one‐pot reaction between substituted aromatic aldehydes, 6‐amino‐1,3‐dimethyluracil, and 10% β‐cyclodextrin‐SO 3 H in water with 84%–92% yield within 20–120 min. The salient features of this protocol included water as green solvent, β‐cyclodextrin‐SO 3 H as recyclable supramolecular catalyst, mild reaction conditions, easy isolation of pure products, and good to excellent yields.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202404650